Version 1
: Received: 30 July 2024 / Approved: 1 August 2024 / Online: 2 August 2024 (04:06:34 CEST)
How to cite:
Urbanski, A. H.; Escolano Maso, V.; de Mello Martins, F.; da Costa-Martins, A. G.; Barbosa do Nascimento Oliveira, A. P.; Nakaya, H. I. Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival. Preprints2024, 2024080080. https://doi.org/10.20944/preprints202408.0080.v1
Urbanski, A. H.; Escolano Maso, V.; de Mello Martins, F.; da Costa-Martins, A. G.; Barbosa do Nascimento Oliveira, A. P.; Nakaya, H. I. Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival. Preprints 2024, 2024080080. https://doi.org/10.20944/preprints202408.0080.v1
Urbanski, A. H.; Escolano Maso, V.; de Mello Martins, F.; da Costa-Martins, A. G.; Barbosa do Nascimento Oliveira, A. P.; Nakaya, H. I. Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival. Preprints2024, 2024080080. https://doi.org/10.20944/preprints202408.0080.v1
APA Style
Urbanski, A. H., Escolano Maso, V., de Mello Martins, F., da Costa-Martins, A. G., Barbosa do Nascimento Oliveira, A. P., & Nakaya, H. I. (2024). Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival. Preprints. https://doi.org/10.20944/preprints202408.0080.v1
Chicago/Turabian Style
Urbanski, A. H., Ana Paula Barbosa do Nascimento Oliveira and Helder I. Nakaya. 2024 "Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast Survival" Preprints. https://doi.org/10.20944/preprints202408.0080.v1
Abstract
Infection with the Chikungunya virus (CHIKV) manifests as a febrile illness known as chikungunya fever (CHIKF). CHIKF is characterized by sudden-onset high fever, rash, polyarthritis, and polyarthralgia. Alt-hough the infection typically resolves within two weeks, many patients experience recurrent joint pain and inflammation that can outlast the other symptoms for many months. CHIKF has been previously linked to rheumatoid arthritis (RA) due to similar inflammatory processes. This study aimed to identify molecular markers in the blood of CHIKV-infected individuals associated with joint pain and chronicity of CHIKF. Sequencing of B and T cell receptors (BCR and TCR) revealed that CHIKV infection reduces CDR3 diver-sity. Lower BCR diversity was linked to increased expression of genes involved in osteoclast differentiation and activation through RANK/RANKL signaling. If osteoclast involvement in CHIKF pathogenesis is con-firmed, existing therapeutic approaches could be used as alternative treatments for CHIKF patients.
Keywords
Chikungunya fever; Rheumatoid arthritis; RANK signaling; CDR3; B cells; T cells
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
