Version 1
: Received: 31 July 2024 / Approved: 1 August 2024 / Online: 2 August 2024 (02:52:59 CEST)
How to cite:
Oyarzun, I.; Hernández, G.; Sala-Padró, J.; Morandeira, F.; Casasnovas, C.; Falip, M. Epilepsy and Myasthenia Gravis, a Case Series. Preprints2024, 2024080091. https://doi.org/10.20944/preprints202408.0091.v1
Oyarzun, I.; Hernández, G.; Sala-Padró, J.; Morandeira, F.; Casasnovas, C.; Falip, M. Epilepsy and Myasthenia Gravis, a Case Series. Preprints 2024, 2024080091. https://doi.org/10.20944/preprints202408.0091.v1
Oyarzun, I.; Hernández, G.; Sala-Padró, J.; Morandeira, F.; Casasnovas, C.; Falip, M. Epilepsy and Myasthenia Gravis, a Case Series. Preprints2024, 2024080091. https://doi.org/10.20944/preprints202408.0091.v1
APA Style
Oyarzun, I., Hernández, G., Sala-Padró, J., Morandeira, F., Casasnovas, C., & Falip, M. (2024). Epilepsy and Myasthenia Gravis, a Case Series. Preprints. https://doi.org/10.20944/preprints202408.0091.v1
Chicago/Turabian Style
Oyarzun, I., Carlos Casasnovas and Mercè Falip. 2024 "Epilepsy and Myasthenia Gravis, a Case Series" Preprints. https://doi.org/10.20944/preprints202408.0091.v1
Abstract
Introduction: The association between epilepsy and myasthenia gravis has rarely been reported, and only in small case series. Objective: To report the frequency of epilepsy and myasthenia gravis and to describe a case series of patients with myasthenia gravis and epilepsy, focusing on their clinical characteristics and searching for a possible physiopathological mechanism. Methods: A retrospective, observational, adult center study was conducted in 2022. Patients were recruited from the database of the outpatient clinic of the Myasthenia Gravis unit and Epilepsy unit. Results: Five patients were included. Frequency of epilepsy in the myasthenia gravis cohort was 5/469 (1.1%), and of myasthenia gravis in the epilepsy cohort was 5/1432 (0.35%). All patients suffered focal epilepsy, mainly fronto-central, and drug-resistant in half of them. Myasthenia gravis was generalized and with exacerbations in half of them. Three patients were thymectomized. Other autoimmune diseases were found in 2 (40%). Epilepsy onset preceded myasthenia gravis onset in all patients. Both diseases were considered autoimmune-related in 3/5 (60%). Conclusion: Epilepsy and myasthenia gravis are only infrequently associated. In adult patients, epilepsy onset precedes myasthenia onset in most cases. In some cases, epilepsy has an autoimmune aetiology and coexists with other autoimmune conditions.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
