Version 1
: Received: 1 August 2024 / Approved: 2 August 2024 / Online: 3 August 2024 (16:06:22 CEST)
How to cite:
Bulava, E.; Vorobyeva, I. V.; Dmitriev, I. V.; Balkarov, A. G. Retinal Hemoperfusion and Vascular Endothelial Function after Pancreatic Transplantation. Preprints2024, 2024080147. https://doi.org/10.20944/preprints202408.0147.v1
Bulava, E.; Vorobyeva, I. V.; Dmitriev, I. V.; Balkarov, A. G. Retinal Hemoperfusion and Vascular Endothelial Function after Pancreatic Transplantation. Preprints 2024, 2024080147. https://doi.org/10.20944/preprints202408.0147.v1
Bulava, E.; Vorobyeva, I. V.; Dmitriev, I. V.; Balkarov, A. G. Retinal Hemoperfusion and Vascular Endothelial Function after Pancreatic Transplantation. Preprints2024, 2024080147. https://doi.org/10.20944/preprints202408.0147.v1
APA Style
Bulava, E., Vorobyeva, I. V., Dmitriev, I. V., & Balkarov, A. G. (2024). Retinal Hemoperfusion and Vascular Endothelial Function after Pancreatic Transplantation. Preprints. https://doi.org/10.20944/preprints202408.0147.v1
Chicago/Turabian Style
Bulava, E., Ilya V. Dmitriev and Aslan G. Balkarov. 2024 "Retinal Hemoperfusion and Vascular Endothelial Function after Pancreatic Transplantation" Preprints. https://doi.org/10.20944/preprints202408.0147.v1
Abstract
Introduction: ophthalmological assessment of the retinal circulation and the level of VEGF-A is currently considered a non-invasive and safe diagnostic tool to assess the peripheral microcircu-lation
Objective: to study retinal hemodynamics and VEGF-A levels in patients with type 1 diabetes mellitus after pancreas transplantation
Settings and Design:
A prospective, single-stage, single-center, non-randomized clinical trial
Methods: 79 patients (158 eyes) with type 1 diabetes mellitus and end-stage diabetic nephropathy participated in the study. Patients were divided into 3 groups: group 1, potential recipients of pancreas and kidney transplant from the waiting list; group 2, patients after kidney transplanta-tion; and group 3, patients after simultaneous pancreas and kidney transplantation. Ophthalmo-logical examination included measuring the macular hemoperfusion density. The level of VEGF-A was examined in the patients' tear by enzyme immunoassay.
Results: retinal hemoperfusion density and VEGF-A concentration were expected to correlate with the severity of diabetic changes in the fundus of patients. A lower index of retinal hemoperfusion density and a high level of VEGF-A were noted in patients with proliferative ret-inopathy and macular oedema. Group 3 showed the lowest frequency of the active phase of the proliferative retinopathy and retinal macular oedema, characterized by a higher retinal hemoperfusion density in the foveal and the parafoveal zone of the macular region, and low VEGF-A concentration in tear.
Conclusion: measurement of retinal hemoperfusion density and determination of tear VEGF-A concentration are informative objective methods for diagnosing the severity of diabetic changes of the fundus.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
