Version 1
: Received: 2 August 2024 / Approved: 2 August 2024 / Online: 2 August 2024 (11:51:23 CEST)
How to cite:
Du, J.; Zhao, X.; Ding, X.; Han, Q.; Duan, Y.; Ren, Q.; Wang, H.; Song, C.; Wang, X.; Zhang, D.; Zhu, H. The Role of the Gut Microbiota in Complications among Hemodialysis Patients. Preprints2024, 2024080153. https://doi.org/10.20944/preprints202408.0153.v1
Du, J.; Zhao, X.; Ding, X.; Han, Q.; Duan, Y.; Ren, Q.; Wang, H.; Song, C.; Wang, X.; Zhang, D.; Zhu, H. The Role of the Gut Microbiota in Complications among Hemodialysis Patients. Preprints 2024, 2024080153. https://doi.org/10.20944/preprints202408.0153.v1
Du, J.; Zhao, X.; Ding, X.; Han, Q.; Duan, Y.; Ren, Q.; Wang, H.; Song, C.; Wang, X.; Zhang, D.; Zhu, H. The Role of the Gut Microbiota in Complications among Hemodialysis Patients. Preprints2024, 2024080153. https://doi.org/10.20944/preprints202408.0153.v1
APA Style
Du, J., Zhao, X., Ding, X., Han, Q., Duan, Y., Ren, Q., Wang, H., Song, C., Wang, X., Zhang, D., & Zhu, H. (2024). The Role of the Gut Microbiota in Complications among Hemodialysis Patients. Preprints. https://doi.org/10.20944/preprints202408.0153.v1
Chicago/Turabian Style
Du, J., Dong Zhang and Hanyu Zhu. 2024 "The Role of the Gut Microbiota in Complications among Hemodialysis Patients" Preprints. https://doi.org/10.20944/preprints202408.0153.v1
Abstract
The composition of the gut microbiota varies among end-stage renal disease (ESRD) patients on the basis of their mode of renal replacement therapy (RRT), with notably more pronounced dysbiosis in those undergoing hemodialysis (HD). Interventions such as dialysis catheters, unstable hemodynamics, strict dietary restrictions, and pharmacotherapy significantly alter the intestinal microenvironment, thus disrupting the gut microbiota composition in HD patients. The gut microbiota may influence HD-related complications, including cardiovascular disease (CVD), infections, anemia, and malnutrition, through mechanisms such as bacterial translocation, immune regulation, and the production of gut bacterial metabolites, thereby affecting both the quality of life and the prognosis of patients. This review focuses on alterations in the gut microbiota and its metabolites in HD patients. Additionally, understanding the impact of the gut microbiota on the complications of HD could provide insights into the development of novel treatment strategies to prevent or alleviate complications in HD patients.
Keywords
gut microbiota; hemodialysis; complications; uremic toxins
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
