Version 1
: Received: 21 July 2024 / Approved: 2 August 2024 / Online: 2 August 2024 (11:55:45 CEST)
How to cite:
Zhou, Q.; Gao, W.; Zhang, W.; Tang, S.; Fu, H.; Pan, P. Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in Sepsis. Preprints2024, 2024080155. https://doi.org/10.20944/preprints202408.0155.v1
Zhou, Q.; Gao, W.; Zhang, W.; Tang, S.; Fu, H.; Pan, P. Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in Sepsis. Preprints 2024, 2024080155. https://doi.org/10.20944/preprints202408.0155.v1
Zhou, Q.; Gao, W.; Zhang, W.; Tang, S.; Fu, H.; Pan, P. Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in Sepsis. Preprints2024, 2024080155. https://doi.org/10.20944/preprints202408.0155.v1
APA Style
Zhou, Q., Gao, W., Zhang, W., Tang, S., Fu, H., & Pan, P. (2024). Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in Sepsis. Preprints. https://doi.org/10.20944/preprints202408.0155.v1
Chicago/Turabian Style
Zhou, Q., Hongxue Fu and Pengfei Pan. 2024 "Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in Sepsis" Preprints. https://doi.org/10.20944/preprints202408.0155.v1
Abstract
Sepsis, characterized by a dysregulated systemic inflammatory response to infection, remains a significant global health burden, despite substantial advancements in its treatment. An understanding of the underlying mechanisms driving sepsis is crucial for the development of targeted therapeutic strategies. Silent information regulator 1 (SIRT1), a member of the class III histone deacetylases, plays a pivotal role in regulating gene expression by catalyzing the deacetylation of lysine residues on non-histone and histone proteins. With the advancement of sepsis research, SIRT1 has been shown to exert significant anti-inflammatory, anti-oxidative, anti-apoptotic, and metabolic regulatory effects, positioning it as a potential therapeutic target for sepsis. This article reviews the latest progress on research into the signaling pathways modulated by SIRT1 in sepsis and its associated regulatory mechanisms to further elucidate the pathogenesis of sepsis and assist in guiding clinical treatment.
Keywords
silent information regulator 1; sepsis; regulatory mechanism; signaling pathway; progression
Subject
Medicine and Pharmacology, Emergency Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
