Version 1
: Received: 2 August 2024 / Approved: 3 August 2024 / Online: 5 August 2024 (08:18:16 CEST)
How to cite:
Sebastião, C.; Cassinela, E.; Manuel, V.; Matary, W.; Nkuku, M.; Piedade, I.; Filipe, C.; Cristóvão, L.; Sacomboio, E. Dynamics of Liver Function among Patients with Malaria in Luanda, Angola: A Cross-Sectional Study. Preprints2024, 2024080224. https://doi.org/10.20944/preprints202408.0224.v1
Sebastião, C.; Cassinela, E.; Manuel, V.; Matary, W.; Nkuku, M.; Piedade, I.; Filipe, C.; Cristóvão, L.; Sacomboio, E. Dynamics of Liver Function among Patients with Malaria in Luanda, Angola: A Cross-Sectional Study. Preprints 2024, 2024080224. https://doi.org/10.20944/preprints202408.0224.v1
Sebastião, C.; Cassinela, E.; Manuel, V.; Matary, W.; Nkuku, M.; Piedade, I.; Filipe, C.; Cristóvão, L.; Sacomboio, E. Dynamics of Liver Function among Patients with Malaria in Luanda, Angola: A Cross-Sectional Study. Preprints2024, 2024080224. https://doi.org/10.20944/preprints202408.0224.v1
APA Style
Sebastião, C., Cassinela, E., Manuel, V., Matary, W., Nkuku, M., Piedade, I., Filipe, C., Cristóvão, L., & Sacomboio, E. (2024). Dynamics of Liver Function among Patients with Malaria in Luanda, Angola: A Cross-Sectional Study. Preprints. https://doi.org/10.20944/preprints202408.0224.v1
Chicago/Turabian Style
Sebastião, C., Lourenço Cristóvão and Euclides Sacomboio. 2024 "Dynamics of Liver Function among Patients with Malaria in Luanda, Angola: A Cross-Sectional Study" Preprints. https://doi.org/10.20944/preprints202408.0224.v1
Abstract
Background: Malaria continues a concern in Angola. Liver dysfunction is a relevant feature of malaria. There is no published study exploring liver function dynamics during P.falciparum infection in Angola.Objectives: We investigated the dynamics of liver function among patients with malaria in Luanda, Angola.Methods: This was a cross-sectional study performed with 199 malaria patients, from March-August 2023.Results: About 71% of the patients had low parasitemia, moderate disease(54%), and used Artesunato(39.7%). Decrease in ALT(68.7 to 50.7) was observed from non-severe to severe with increases in AST(56.6 to 134, p<0.05), GGT(51.2 to 99.0), and Bilirubin(0.72 to 1029). We observed higher ALT values in patients using Artimeter, while higher AST and GGT in patients using Artesunate. Higher Bilirubin was observed in patients treated with Coarten. Differences in AST values depending on the antimalarial used were significant(p<0.05). AB blood group presented high AST and GGT values, group B presented high ALT while high Bilirubin was observed in group O. Differences in GGT depending on the blood groups were significant(p<0.05). Elevated ALT, AST, GGT, and Bilirubin were observed in Rh-positive.Conclusions: Several malarian patients could present high AST, ALT, GGT, and Bilirubin values indicating putative liver failure during malaria treatment in Angola.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
