Version 1
: Received: 4 August 2024 / Approved: 4 August 2024 / Online: 6 August 2024 (06:09:10 CEST)
How to cite:
Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1
Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints 2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1
Furci, F.; Scaramozzino, M. U.; Talesa, G. R.; Crea, G. G.; Pelaia, C. Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints2024, 2024080228. https://doi.org/10.20944/preprints202408.0228.v1
APA Style
Furci, F., Scaramozzino, M. U., Talesa, G. R., Crea, G. G., & Pelaia, C. (2024). Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis. Preprints. https://doi.org/10.20944/preprints202408.0228.v1
Chicago/Turabian Style
Furci, F., Giusi Gisella Crea and Corrado Pelaia. 2024 "Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis" Preprints. https://doi.org/10.20944/preprints202408.0228.v1
Abstract
Asthma is a chronic inflammatory disease for which the main anti-inflammatory drugs for better disease control are steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fractures. A single oral corticosteroids course increases the risk of osteoporosis and continual use of inhaled corticosteroids is correlated over time to an increased risk for both bone conditions. With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in what are the steps of therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis.
Keywords
severe asthma; biologics; corticosteroids; inflammation; interleukins; osteoporosis
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
