Version 1
: Received: 4 August 2024 / Approved: 5 August 2024 / Online: 5 August 2024 (08:18:42 CEST)
How to cite:
Bonastre-Férez, J.; Giménez-Orenga, K.; Falaguera-Vera, F. J.; Garcia-Escudero, M.; Oltra, E. Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1. Preprints2024, 2024080257. https://doi.org/10.20944/preprints202408.0257.v1
Bonastre-Férez, J.; Giménez-Orenga, K.; Falaguera-Vera, F. J.; Garcia-Escudero, M.; Oltra, E. Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1. Preprints 2024, 2024080257. https://doi.org/10.20944/preprints202408.0257.v1
Bonastre-Férez, J.; Giménez-Orenga, K.; Falaguera-Vera, F. J.; Garcia-Escudero, M.; Oltra, E. Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1. Preprints2024, 2024080257. https://doi.org/10.20944/preprints202408.0257.v1
APA Style
Bonastre-Férez, J., Giménez-Orenga, K., Falaguera-Vera, F. J., Garcia-Escudero, M., & Oltra, E. (2024). Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1. Preprints. https://doi.org/10.20944/preprints202408.0257.v1
Chicago/Turabian Style
Bonastre-Férez, J., María Garcia-Escudero and Elisa Oltra. 2024 "Manual Therapy Improves Fibromyalgia Symptoms by Downregulating SIK1" Preprints. https://doi.org/10.20944/preprints202408.0257.v1
Abstract
Fibromyalgia (FM), classified by ICD-11 with code MG30.0, is a chronic debilitating disease characterized by wide-spread pain, fatigue, cognitive impairment, sleep and intestinal alterations, among other. FM affects a large proportion of the world-wide population, with increased prevalence among women. The lack of understanding of its etiology and pathophysiology hampers the development of effective treatments. Our group had developed a manual therapy (MT) pressure-controlled custom manual protocol on FM showing hyperalgesia/allodynia, fatigue and patient’s quality of life benefits in a cohort of 38 FM cases (NCT04174300). With the aim of understanding the therapeutic molecular mechanisms triggered by MT, this study interrogated PBMC transcriptomes from FM participants of this clinical trial using RNAseq and RT-qPCR technologies. The results showed that the salt-induced kinase SIK-1 was consistently downregulated by MT in FM, correlating with improvement of patient symptoms. In addition, the study compared the findings in a non-FM control cohort subjected to the same MT protocol evidencing that the changes in SIK1 with MT only occurred in individuals with FM. This positions SIK-1 as a potential biomarker to monitor response to MT, and as a therapeutic target of FM, to be further explored by continuation studies.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
