Version 1
: Received: 1 August 2024 / Approved: 6 August 2024 / Online: 6 August 2024 (06:52:09 CEST)
How to cite:
Noh, J.-W.; Yoo, J.-H.; Lee, B.-C. Enhanced Anti-Obesity Effects of Euphorbia Kansui Extract through Macrophage and Gut Microbiota Modulation: A Real-World Clinical and In Vivo Study. Preprints2024, 2024080397. https://doi.org/10.20944/preprints202408.0397.v1
Noh, J.-W.; Yoo, J.-H.; Lee, B.-C. Enhanced Anti-Obesity Effects of Euphorbia Kansui Extract through Macrophage and Gut Microbiota Modulation: A Real-World Clinical and In Vivo Study. Preprints 2024, 2024080397. https://doi.org/10.20944/preprints202408.0397.v1
Noh, J.-W.; Yoo, J.-H.; Lee, B.-C. Enhanced Anti-Obesity Effects of Euphorbia Kansui Extract through Macrophage and Gut Microbiota Modulation: A Real-World Clinical and In Vivo Study. Preprints2024, 2024080397. https://doi.org/10.20944/preprints202408.0397.v1
APA Style
Noh, J. W., Yoo, J. H., & Lee, B. C. (2024). Enhanced Anti-Obesity Effects of Euphorbia Kansui Extract through Macrophage and Gut Microbiota Modulation: A Real-World Clinical and In Vivo Study. Preprints. https://doi.org/10.20944/preprints202408.0397.v1
Chicago/Turabian Style
Noh, J., Jung-Hwa Yoo and Byung-Cheol Lee. 2024 "Enhanced Anti-Obesity Effects of Euphorbia Kansui Extract through Macrophage and Gut Microbiota Modulation: A Real-World Clinical and In Vivo Study" Preprints. https://doi.org/10.20944/preprints202408.0397.v1
Abstract
Rising obesity and associated multi-systemic complications amplify the health burden. Euphorbia kansui (EK) extract is clinically recognized for managing obesity. In human study, 240 obese individuals were categorized into two cohorts: those receiving solely herbal medicine (HM group), and those administered EK concomitantly with herbal medicine (EK group). An in vivo examination using C57BL/6-Lepob/Lepob mice elucidated mechanisms involving macrophages and gut microbiota, with associated metabolic advantages. The clinical study revealed a significant 7.22% body weight reduction during 91.55 average treatment days, and examined 16.71% weight loss at 300 days after treatment. In the whole subjects, 60.4%, 21.3% and 6.3% achieved weight reductions exceeding 5%, 10% and 15%, respectively. Impressively, the EK group exhibited superior weight loss compared to the HM group (EK: -7.73% vs. HM: -6.27%, p=0.012). The anti-obesity effect was positively associated with EK therapy frequency and herbal medicine duration. In vivo, EK significantly improved insulin sensitivity and mitigated infiltration of adipose tissue macrophages (ATMs) by modulating the CD11c+ and CD206+ subtypes. EK also correlated with increased Bacteroidetes and Firmicutes populations and reduced Proteobacteria and Verrucomicrobia. Consequently, EK is an effective adjunctive anti-obesity therapy offering metabolic benefits by modulating ATMs and gut microbiota profiles.
Keywords
Keywords Anti-obesity; herbal remedies; Euphorbia kansui; insulin resistance; gut microbiota; adipose tissue macrophage; weight management.
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
