Feng, F., Li Yao and Xiuyu Wang. 2024 "Tumor Microenvironment-Responsive Magnetotactic Bacteria-Based Multi-drug Delivery Platform for MRI-Visualized Tumor Photothermal− Chemodynamic Therapy" Preprints. https://doi.org/10.20944/preprints202408.0458.v1
Abstract
Cancer cells display elevated reactive oxygen species (ROS) and altered redox status, Here based on these characteristics, we develop a multi-drug delivery platform AMB@PDAP-Fe (APPF), from magnetotactic bacterium AMB-1 and realize MRI-visualized tumor microenvironment-responsive photothermal-chemodynamic therapy. The Fe3+ in PDAP-Fe is reduced by the GSH at tumor site and is released in the form of highly active Fe2+, which catalyzes the generation of ROS through Fenton reaction and inhibits tumor growth. At the same time, the significant absorption of the mineralized magnetosomes in AMB-1 cells in the NIR region enable them to efficiently convert near-infrared light into heat energy for photothermal therapy (PTT), to which PDAP also contributes. The heat generated in the PTT process accelerates the process of Fe2+ release, thereby achieving an enhanced Fenton reaction in tumor microenvironment. In addition, the magnetosomes in AMB-1 are used as MRI contrast agent, and the curing process is visualized. This tumor microenvironment-responsive MTB-based multi-drug delivery platform displays a potency to combat tumor and demonstrates the utility and practicality of understanding the cooperative molecular mechanism when designing multi-drug combination therapies.
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