Preprint Article Version 1 This version is not peer-reviewed

The Synergistic Combination of Curcumin and Polydatin Improves Temozolomide Efficacy on Glioblastoma Cells

Version 1 : Received: 7 August 2024 / Approved: 7 August 2024 / Online: 8 August 2024 (09:03:56 CEST)

How to cite: Serafino, A.; Krasnowska, E. K.; Romanò, S.; De Gregorio, A.; Colone, M.; Dupuis, M. L.; Bonucci, M.; Ravagnan, G.; Stringaro, A.; Fuggetta, M. P. The Synergistic Combination of Curcumin and Polydatin Improves Temozolomide Efficacy on Glioblastoma Cells. Preprints 2024, 2024080553. https://doi.org/10.20944/preprints202408.0553.v1 Serafino, A.; Krasnowska, E. K.; Romanò, S.; De Gregorio, A.; Colone, M.; Dupuis, M. L.; Bonucci, M.; Ravagnan, G.; Stringaro, A.; Fuggetta, M. P. The Synergistic Combination of Curcumin and Polydatin Improves Temozolomide Efficacy on Glioblastoma Cells. Preprints 2024, 2024080553. https://doi.org/10.20944/preprints202408.0553.v1

Abstract

Glioblastoma (GBL) is one of the more malignant primary brain tumors, currently treated by a multimodality strategy including surgery, radio- and chemotherapy, mainly consisting of Temozolomide(TMZ)-based chemotherapy. Tumor relapse often occurs due to the establishment of TMZ resistance, with a patient median survival

Keywords

curcumin; polydatin; temozolomide; chemoresistance; glioblastoma

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

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