Preprint Review Version 1 This version is not peer-reviewed

Grover Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?

Roxana Nedelcu
,
Alexandra Dobre
* ,
Gabriela Turcu
* ,
Razvan Andrei
,
Elena Balasescu
,
Florentina Pantelimon
,
Mihaela David-Niculescu
,
Adina Dobritoiu
,
Raluca Radu
,
Georgiana Zaharia
,
Ionela Hulea
,
Alice Brinzea
,
Lorena Manea
,
Mihaela Gherghiceanu
,
Daniela Ion
Version 1 : Received: 7 August 2024 / Approved: 7 August 2024 / Online: 8 August 2024 (12:07:22 CEST)

How to cite: Nedelcu, R.; Dobre, A.; Turcu, G.; Andrei, R.; Balasescu, E.; Pantelimon, F.; David-Niculescu, M.; Dobritoiu, A.; Radu, R.; Zaharia, G.; Hulea, I.; Brinzea, A.; Manea, L.; Gherghiceanu, M.; Ion, D. Grover Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?. Preprints 2024, 2024080585. https://doi.org/10.20944/preprints202408.0585.v1 Nedelcu, R.; Dobre, A.; Turcu, G.; Andrei, R.; Balasescu, E.; Pantelimon, F.; David-Niculescu, M.; Dobritoiu, A.; Radu, R.; Zaharia, G.; Hulea, I.; Brinzea, A.; Manea, L.; Gherghiceanu, M.; Ion, D. Grover Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?. Preprints 2024, 2024080585. https://doi.org/10.20944/preprints202408.0585.v1

Abstract

(1) Background: better mechanistic understanding of desmosome disruption and acantholysis in Grover disease (GD) may improve management of this disease. Recent molecular studies highlighted promising pathways to be explored, by directly comparing GD and selected features of associated skin diseases. The association between GD and cutaneous keratinocyte carcinomas, the most prevalent non-melanoma skin cancers (NMSC), is not completely characterized. (2) Objective: To review the medical literature regarding GD-associated cutaneous keratinocyte cancers, focusing on molecular features, pathophysiological mechanisms and disease associations, to help guide future research and patient management. (3) Result: GD has been associated with a variety of skin conditions, but its association with skin cancers has been rarely reported. Between 1983 and 2024 only 9 scientific papers presented data supporting this association. Interestingly, we found that GD may mimic multiple NMSCs, as few authors reported GD cases misdiagnosed as multiple cutaneous squamous cell carcinomas for more than 4 years, or the presence of superficial basal cell carcinoma–like areas associated with focal acantholysis. (4) Conclusions: (a) GD may be an imitator of multiple NMSCs and (b) the relationship between GD and NMSCs may reveal promising pathways for the mechanistic understanding of desmosome disruption and acantholysis in GD and may even lead to its reclassification as a distinctive syndrome.

Keywords

cutaneous keratinocyte cancers; non-melanoma; basal cell carcinomas; cutaneous squamous cell carcinomas; Grover disease; transient acantholytic dermatosis

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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