Version 1
: Received: 8 August 2024 / Approved: 8 August 2024 / Online: 12 August 2024 (03:05:44 CEST)
How to cite:
Pan, Y.; Li, J.; Fan, Z.; Chen, Y.; Huang, X.; Wu, D. New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics. Preprints2024, 2024080662. https://doi.org/10.20944/preprints202408.0662.v1
Pan, Y.; Li, J.; Fan, Z.; Chen, Y.; Huang, X.; Wu, D. New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics. Preprints 2024, 2024080662. https://doi.org/10.20944/preprints202408.0662.v1
Pan, Y.; Li, J.; Fan, Z.; Chen, Y.; Huang, X.; Wu, D. New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics. Preprints2024, 2024080662. https://doi.org/10.20944/preprints202408.0662.v1
APA Style
Pan, Y., Li, J., Fan, Z., Chen, Y., Huang, X., & Wu, D. (2024). New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics. Preprints. https://doi.org/10.20944/preprints202408.0662.v1
Chicago/Turabian Style
Pan, Y., Xiaoxuan Huang and Dong Wu. 2024 "New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics" Preprints. https://doi.org/10.20944/preprints202408.0662.v1
Abstract
Chronic pancreatitis is a progressive fibroinflammatory disorder with no currently satisfactory treatment. Emerging evidence suggests an association between gut microbial dysbiosis and chronic pancreatitis. Although direct causative evidence is lacking, it is hypothesized that the gut microbiota may play a pivotal role in modulating pancreatic function via the gut-pancreas axis. Thus, modulating the gut microbiota through the administration of probiotics or prebiotics may alleviate pancreatic disorders. In this review, we first propose the potential mechanisms by which specific probiotics or prebiotics may ameliorate chronic pancreatitis, including the alleviation of small intestinal bacterial overgrowth (SIBO), facilitation of short-chain fatty acids (SCFAs) production, activation of the glucagon-like peptide 1 receptors (GLP-1Rs) in the pancreas. Since there are currently no probiotics or prebiotics used for the treatment of chronic pancreatitis, we have discussed research in other disease models that use probiotics or prebiotics to modulate pancreatic endocrine and exocrine functions and prevent pancreatic fibrosis. This provides indirect evidence for their potential application in the treatment of chronic pancreatitis. We anticipate that this research will stimulate further investigation into the gut-pancreas axis and the potential therapeutic value of probiotics and prebiotics in chronic pancreatitis.
Keywords
chronic pancreatitis; probiotics; prebiotics; gut microbiota
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
