Version 1
: Received: 10 August 2024 / Approved: 12 August 2024 / Online: 12 August 2024 (12:32:36 CEST)
How to cite:
Tuwleh, L.; Hamraa, J.; Ali, H.; Emmanuel, A. T.; Talee Bropleh, J.; Sharon Rumide, T. An Update on Resurgence of Diphtheria Cases in West Africa: Investigating Factors Behind Outbreaks Despite Annual WHO Vaccination Initiatives. Preprints2024, 2024080814. https://doi.org/10.20944/preprints202408.0814.v1
Tuwleh, L.; Hamraa, J.; Ali, H.; Emmanuel, A. T.; Talee Bropleh, J.; Sharon Rumide, T. An Update on Resurgence of Diphtheria Cases in West Africa: Investigating Factors Behind Outbreaks Despite Annual WHO Vaccination Initiatives. Preprints 2024, 2024080814. https://doi.org/10.20944/preprints202408.0814.v1
Tuwleh, L.; Hamraa, J.; Ali, H.; Emmanuel, A. T.; Talee Bropleh, J.; Sharon Rumide, T. An Update on Resurgence of Diphtheria Cases in West Africa: Investigating Factors Behind Outbreaks Despite Annual WHO Vaccination Initiatives. Preprints2024, 2024080814. https://doi.org/10.20944/preprints202408.0814.v1
APA Style
Tuwleh, L., Hamraa, J., Ali, H., Emmanuel, A. T., Talee Bropleh, J., & Sharon Rumide, T. (2024). An Update on Resurgence of Diphtheria Cases in West Africa: Investigating Factors Behind Outbreaks Despite Annual WHO Vaccination Initiatives. Preprints. https://doi.org/10.20944/preprints202408.0814.v1
Chicago/Turabian Style
Tuwleh, L., Josiah Talee Bropleh and Tolulope Sharon Rumide. 2024 "An Update on Resurgence of Diphtheria Cases in West Africa: Investigating Factors Behind Outbreaks Despite Annual WHO Vaccination Initiatives" Preprints. https://doi.org/10.20944/preprints202408.0814.v1
Abstract
In 2023, approximately 108 million infants worldwide received three doses of the diphtheria-tetanus-pertussis (DTP) vaccine, yet significant disparities persist, particularly in low-resource settings like West Africa. Despite the DPT vaccine's proven efficacy against diphtheria, the region continues to experience high rates of outbreaks for diphtheria, tetanus, and typhoid in 2024. This review aims to highlight the recent diphtheria crisis and analyze the trends and challenges of DTP vaccine coverage in West Africa by shedding light on socio-economic conditions, healthcare facilities and genetic factors. The review seeks to provide insights into improving vaccination rates and public health outcomes in the region, emphasizing the critical role of the DPT vaccine in combating life-threatening diseases. Enhanced surveillance and effective response strategies and development of region specific theraputics by the analysis of genomic variability in Africans, specifically within the human leukocyte antigen (HLA) locus are essential to address the ongoing public health challenges posed by diphtheria and related infections in West Africa.
Keywords
DPT vaccine; effective; re-emergence; diphtheria outbreak; West Africa
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
