Version 1
: Received: 11 August 2024 / Approved: 12 August 2024 / Online: 12 August 2024 (12:49:00 CEST)
How to cite:
Noorintan, S. T.; Angelius, C.; Torizal, F. G. 3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment. Preprints2024, 2024080822. https://doi.org/10.20944/preprints202408.0822.v1
Noorintan, S. T.; Angelius, C.; Torizal, F. G. 3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment. Preprints 2024, 2024080822. https://doi.org/10.20944/preprints202408.0822.v1
Noorintan, S. T.; Angelius, C.; Torizal, F. G. 3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment. Preprints2024, 2024080822. https://doi.org/10.20944/preprints202408.0822.v1
APA Style
Noorintan, S. T., Angelius, C., & Torizal, F. G. (2024). 3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment. Preprints. https://doi.org/10.20944/preprints202408.0822.v1
Chicago/Turabian Style
Noorintan, S. T., Chelsie Angelius and Fuad Gandhi Torizal. 2024 "3D Organoid Models in Cancer Immunotherapy: Bioengineering Approach for Personalized Treatment" Preprints. https://doi.org/10.20944/preprints202408.0822.v1
Abstract
Recent advances in organoid technology have revolutionized cancer biology and thera-peutic interventions, offering personalized immunotherapy treatment. Organoids, three-dimensional cell cultures derived from patient tumors, accurately replicate the tumor microenvi-ronment, providing unprecedented insights into tumor-immune interactions and therapeutic re-sponses. In this literature-based study, we discuss various culture methods for the diverse appli-cations of organoids in cancer immunotherapy, including drug screening, personalized treatment strategies, and mechanistic studies. Additionally, we address the technological challenges asso-ciated with these methods and propose potential future solutions to accelerate the development of novel immunotherapeutic approaches. This review highlights the transformative potential of or-ganoid models in advancing preclinical cancer immunotherapy modeling, screening, and evalua-tion, paving the way for more effective and personalized cancer treatments.
Keywords
3D organoid models; Cancer immunotherapy; Personalized treatment; Bioengineering; Culture methods
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
