Version 1
: Received: 10 August 2024 / Approved: 13 August 2024 / Online: 14 August 2024 (02:30:11 CEST)
How to cite:
Miller, M. R.; Landis, H. E.; Miller, R. E.; Tizabi, Y. Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease. Preprints2024, 2024080889. https://doi.org/10.20944/preprints202408.0889.v1
Miller, M. R.; Landis, H. E.; Miller, R. E.; Tizabi, Y. Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease. Preprints 2024, 2024080889. https://doi.org/10.20944/preprints202408.0889.v1
Miller, M. R.; Landis, H. E.; Miller, R. E.; Tizabi, Y. Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease. Preprints2024, 2024080889. https://doi.org/10.20944/preprints202408.0889.v1
APA Style
Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024). Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease. Preprints. https://doi.org/10.20944/preprints202408.0889.v1
Chicago/Turabian Style
Miller, M. R., Robert E Miller and Yousef Tizabi. 2024 "Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease" Preprints. https://doi.org/10.20944/preprints202408.0889.v1
Abstract
Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important adhesion molecules during leukocyte recruitment. It is encoded by the ICAM1 gene and plays a central role in inflammation. It’s crucial role in many inflammatory diseases such as ulcerative colitis and rheumatoid arthritis are well established. Given that neuroinflammation, underscored by microglial activation, is a key element in neurodegenerative diseases such as Parkinson’s disease (PD), we investigated whether ICAM-1 has a role in this progressive neurological condition and if so, elucidate the underpinning mechanisms. Specifically, we were interested in potential interaction between ICAM-1, glial cells and ferroptosis, an iron-dependent form of cell death that has recently been implicated in PD. We conclude that there exist direct and indirect (via glial cells and T cells) influences of ICAM-1 on ferroptosis and that further elucidation of these interactions can suggest novel intervention for this devastating disease.
Keywords
ICAM-1; Parkinson’s disease; Ferroptosis; Glial cells; T cells; Neuroinflammation
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
