Tau and Depression: A Systematic Review

JULIANO FLAVIO RUBATINO RODRIGUES; Lívia Rodrigues; Franciany Rodrigues; Fernando Rubatino; Kelly Atalaia da Silva; María Fernanda Serna Rodriguez; Hannes Fischer; Pedro Marco Karan Barbosa; Spencer Payão; Moacir Godoy; Gerardo de Araújo Filho

doi:10.20944/preprints202408.0925.v1

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preprints.org > medicine and pharmacology > psychiatry and mental health > doi: 10.20944/preprints202408.0925.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Tau and Depression: A Systematic Review

JULIANO FLAVIO RUBATINO RODRIGUES

^* ,

Lívia Rodrigues

Franciany Rodrigues

Fernando Rubatino

Kelly Atalaia da Silva

María Fernanda Serna Rodriguez

Hannes Fischer

Pedro Marco Karan Barbosa

Spencer Payão

Moacir Godoy

Gerardo de Araújo Filho

Version 1 : Received: 12 August 2024 / Approved: 13 August 2024 / Online: 13 August 2024 (11:13:14 CEST)

How to cite: RUBATINO RODRIGUES, J. F.; Rodrigues, L.; Rodrigues, F.; Rubatino, F.; Atalaia da Silva, K.; Serna Rodriguez, M. F.; Fischer, H.; Karan Barbosa, P. M.; Payão, S.; Godoy, M.; de Araújo Filho, G. Tau and Depression: A Systematic Review. Preprints 2024, 2024080925. https://doi.org/10.20944/preprints202408.0925.v1 RUBATINO RODRIGUES, J. F.; Rodrigues, L.; Rodrigues, F.; Rubatino, F.; Atalaia da Silva, K.; Serna Rodriguez, M. F.; Fischer, H.; Karan Barbosa, P. M.; Payão, S.; Godoy, M.; de Araújo Filho, G. Tau and Depression: A Systematic Review. Preprints 2024, 2024080925. https://doi.org/10.20944/preprints202408.0925.v1

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MDPI and ACS Style

RUBATINO RODRIGUES, J. F.; Rodrigues, L.; Rodrigues, F.; Rubatino, F.; Atalaia da Silva, K.; Serna Rodriguez, M. F.; Fischer, H.; Karan Barbosa, P. M.; Payão, S.; Godoy, M.; de Araújo Filho, G. Tau and Depression: A Systematic Review. Preprints 2024, 2024080925. https://doi.org/10.20944/preprints202408.0925.v1

APA Style

RUBATINO RODRIGUES, J. F., Rodrigues, L., Rodrigues, F., Rubatino, F., Atalaia da Silva, K., Serna Rodriguez, M. F., Fischer, H., Karan Barbosa, P. M., Payão, S., Godoy, M., & de Araújo Filho, G. (2024). Tau and Depression: A Systematic Review. Preprints. https://doi.org/10.20944/preprints202408.0925.v1

Chicago/Turabian Style

RUBATINO RODRIGUES, J. F., Moacir Godoy and Gerardo de Araújo Filho. 2024 "Tau and Depression: A Systematic Review" Preprints. https://doi.org/10.20944/preprints202408.0925.v1

Abstract

Objectives: The tau protein is essential for stabilizing microtubules. Changes in its phosphorylation are identified in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. The hyperphosphorylation of the tau protein is linked to various factors, including stress, which has a substantial impact on depressive illness. The present study aimed to systematically review studies that describe the association between tau protein and depression.Design: The present study used the PRISMA statement 2020 as the inclusion criterion for articles describing tau protein in individuals with depression. The exclusion criterion was the lack of comparison of tau protein levels with individuals without depression.Results: A total of 138 papers were identified, of which 21 were ultimately included. One out of every three articles included demonstrated the statistical significance of the tau protein values between the depression group and controls. Only one had an adequate sample but demonstrated results without any major significance.Conclusions: The association between tau protein and depression remains unclear. Studies with adequate sampling are necessary to answer this question.

Keywords

tau; tau proteins; tauopathies; depression; systematic review

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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