Version 1
: Received: 12 August 2024 / Approved: 13 August 2024 / Online: 13 August 2024 (14:33:46 CEST)
How to cite:
Jimenez, C.; Martí-Carretero, A.; Villagrasa, A.; Aguilar, A.; Perez, M.; Ventura, M.; Vargas, V. Bacterial Infections Features in Alcohol-Associated Hepatitis: Review of a 2016–2021 Cohort. Preprints2024, 2024080936. https://doi.org/10.20944/preprints202408.0936.v1
Jimenez, C.; Martí-Carretero, A.; Villagrasa, A.; Aguilar, A.; Perez, M.; Ventura, M.; Vargas, V. Bacterial Infections Features in Alcohol-Associated Hepatitis: Review of a 2016–2021 Cohort. Preprints 2024, 2024080936. https://doi.org/10.20944/preprints202408.0936.v1
Jimenez, C.; Martí-Carretero, A.; Villagrasa, A.; Aguilar, A.; Perez, M.; Ventura, M.; Vargas, V. Bacterial Infections Features in Alcohol-Associated Hepatitis: Review of a 2016–2021 Cohort. Preprints2024, 2024080936. https://doi.org/10.20944/preprints202408.0936.v1
APA Style
Jimenez, C., Martí-Carretero, A., Villagrasa, A., Aguilar, A., Perez, M., Ventura, M., & Vargas, V. (2024). Bacterial Infections Features in Alcohol-Associated Hepatitis: Review of a 2016–2021 Cohort. Preprints. https://doi.org/10.20944/preprints202408.0936.v1
Chicago/Turabian Style
Jimenez, C., Meritxell Ventura and Victor Vargas. 2024 "Bacterial Infections Features in Alcohol-Associated Hepatitis: Review of a 2016–2021 Cohort" Preprints. https://doi.org/10.20944/preprints202408.0936.v1
Abstract
Background/Objectives: Bacterial infections (BI) are a major cause of mortality in patients with alcohol-associated hepatitis (AH); however, only a few studies have investigated BI in AH in the last decade. Therefore, we aimed to assess the features and outcomes of BI in patients with AH. Methods: This observational descriptive study included patients with AH admitted to a tertiary academic hospital between 2016–2021. Clinical and complete microbiological data were recorded and complications, including acute-on-chronic liver failure (ACLF), and mortality over 90-days were compared between infected and non-infected patients. Results: Overall, 115 patients with AH were recruited and 75 had severe AH; among them, 66 started corticosteroid treatment. We identified 69 cases of BI in 44 patients; the incidence of BI at hospital discharge was 32.2%, which reached 38.2% at 90 days. The predominant infection site was the chest (35%). Among the identified bacteria (52.1%), half were gram-positive and half gram-negative. A low rate of multidrug-resistant bacteria (14%) was also noted. Infected patients during hospitalization (n=37) exhibited higher rates of hepatic decompensation and ACLF p=0.001) and lower survival (81.8% vs. 95.8%, p=0.015) than did non-infected patients (n=78). In-hospital infected patients (n=22) exhibited worse survival (72.7%) than did those infected upon admission (93.3%) or non-infected patients (94.9%) (p=0.009). Corticosteroid-treated patients displayed a nonsignificant increase in the total number of BI; however, without greater mortality. Conclusions: BI were common in our cohort of patients with AH. Patients with in-hospital infections commonly experienced serious complications, including high ACLF and death rates. Infections diagnosed upon admission were treated without affecting survival.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
