Version 1
: Received: 13 August 2024 / Approved: 13 August 2024 / Online: 14 August 2024 (07:24:16 CEST)
How to cite:
Kutaish, H.; Tieng, V.; Tscholl, P. M. The Mini-Pig as an Animal Model for Focal Cartilage Treatment of the Knee – A Comparison to the Domestic Pig. Preprints2024, 2024080981. https://doi.org/10.20944/preprints202408.0981.v1
Kutaish, H.; Tieng, V.; Tscholl, P. M. The Mini-Pig as an Animal Model for Focal Cartilage Treatment of the Knee – A Comparison to the Domestic Pig. Preprints 2024, 2024080981. https://doi.org/10.20944/preprints202408.0981.v1
Kutaish, H.; Tieng, V.; Tscholl, P. M. The Mini-Pig as an Animal Model for Focal Cartilage Treatment of the Knee – A Comparison to the Domestic Pig. Preprints2024, 2024080981. https://doi.org/10.20944/preprints202408.0981.v1
APA Style
Kutaish, H., Tieng, V., & Tscholl, P. M. (2024). The Mini-Pig as an Animal Model for Focal Cartilage Treatment of the Knee – A Comparison to the Domestic Pig. Preprints. https://doi.org/10.20944/preprints202408.0981.v1
Chicago/Turabian Style
Kutaish, H., Vannary Tieng and Philippe Matthias Tscholl. 2024 "The Mini-Pig as an Animal Model for Focal Cartilage Treatment of the Knee – A Comparison to the Domestic Pig" Preprints. https://doi.org/10.20944/preprints202408.0981.v1
Abstract
The study objective is to evaluate the reliability of the Göttingen Mini-pig (G-MP) as a large animal model for preclinical studies addressing articular cartilage treatment procedures. Second this work compared the G-MP to the domestic pig (DP) in terms of surgical anatomy, postoperative management, and follow-up period possibilities and challenges. Six G-MP and four DP underwent a two-stage surgical procedure including cartilage harvesting using a superolateral approach followed by cartilage implantation using a medial parapatellar tendon approach. The superolateral approach exposed 11% (SD ± 5) of the entire trochlea in G-MP and 20% in the DP model. The medial parapatellar tendon approach in G-MP exposed 63% (SD ± 4) of the trochlear surface and exposed 34% (SD ± 13) of the medial femoral condyle, allowing 4 trochlear lesions of 6mm of diameter and one to the medial condyle in 4 out of 6 G-MP and in all DPs. Cartilage thickness was under 1mm in G-MP compared to more than 2mm in DP. Weight-progression was + 4 kg/week in DP and + 0.2 kg/week for G-MP. The G-MP is a feasible model for cartilage research, with adequate access to the joint via the dual approach. Thus enabling 4-5 lesions of 6mm, however a thinner cartilage in the G-MP needs to be considered.
Keywords
Large animal model; mini-pig; cartilage repair; knee joint; parapatellar approach
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
