Version 1
: Received: 12 August 2024 / Approved: 13 August 2024 / Online: 14 August 2024 (00:33:17 CEST)
How to cite:
AbdelMassih, A.; Ramadan, B.; ElDemerdash, J.; Zayed, M.; Soued, M.; El-Husseiny, N.; Husseiny, Y.; Saad, P. Repurposing cGMP Pathway Medications, from Vasodilation towards Changing the Face of Heart Failure. Preprints2024, 2024080984. https://doi.org/10.20944/preprints202408.0984.v1
AbdelMassih, A.; Ramadan, B.; ElDemerdash, J.; Zayed, M.; Soued, M.; El-Husseiny, N.; Husseiny, Y.; Saad, P. Repurposing cGMP Pathway Medications, from Vasodilation towards Changing the Face of Heart Failure. Preprints 2024, 2024080984. https://doi.org/10.20944/preprints202408.0984.v1
AbdelMassih, A.; Ramadan, B.; ElDemerdash, J.; Zayed, M.; Soued, M.; El-Husseiny, N.; Husseiny, Y.; Saad, P. Repurposing cGMP Pathway Medications, from Vasodilation towards Changing the Face of Heart Failure. Preprints2024, 2024080984. https://doi.org/10.20944/preprints202408.0984.v1
APA Style
AbdelMassih, A., Ramadan, B., ElDemerdash, J., Zayed, M., Soued, M., El-Husseiny, N., Husseiny, Y., & Saad, P. (2024). Repurposing cGMP Pathway Medications, from Vasodilation towards Changing the Face of Heart Failure. Preprints. https://doi.org/10.20944/preprints202408.0984.v1
Chicago/Turabian Style
AbdelMassih, A., Yousef Husseiny and Passant Saad. 2024 "Repurposing cGMP Pathway Medications, from Vasodilation towards Changing the Face of Heart Failure" Preprints. https://doi.org/10.20944/preprints202408.0984.v1
Abstract
Background:Advanced heart failure is characterized by repeated hospital admissions due to recurring need for intravenous inotropes. Among the most commonly used medications used in this context, is milrinone, which increases the myocardial relaxation velocity, what is known as lusitropy. This effect is mediated by increasing cyclic AMP, which in turn switches on phospholamban activity, an enzyme promoting calcium reuptake by sarcoplasmic reticulum. The aim of this review is to shed light on oral medications that can play a similar role by alternative pathways. Main Body:Phospholamban can be as well stimulated by cGMP, the latter is known to be increased by medications which inhibit phosphodiesterase 5. Two well-established drugs can perform this action and are currently exclusively used as vasodilators, namely sildenafil and tadalafil. Another emerging hope is vericiguat, a medication that can directly stimulates guanylyl cyclase, leading to increase in cGMP. Conclusion:We speculate that the possible introduction of these oral medications is thought to replace the need for repeated hospital and intensive care admissions. This also might mean, delaying the necessity for mechanical support or transplantations, which can change the face of advanced or end-stage heart failure.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
