Review
Version 1
This version is not peer-reviewed
MicroRNA in human umbilical cord blood
Version 1
: Received: 12 August 2024 / Approved: 13 August 2024 / Online: 14 August 2024 (09:10:24 CEST)
How to cite: Yu, T.; Yuan, Y. MicroRNA in human umbilical cord blood. Preprints 2024, 2024080989. https://doi.org/10.20944/preprints202408.0989.v1 Yu, T.; Yuan, Y. MicroRNA in human umbilical cord blood. Preprints 2024, 2024080989. https://doi.org/10.20944/preprints202408.0989.v1
Abstract
The blood that remains in the placenta and umbilical cord after the birth of the infant is referred to as umbilical cord blood (UCB), which has the advantages of convenient source and less ethical controversy. MicroRNA (miRNA) is a class of non-coding RNAs that can regulate gene expression after translation and transcription. Alterations in miRNA expression involve changes in a range of gene expression pathways. An increasing body of research indicates that miRNAs are implicated in many human disorders and are involved in almost all biological medium processes. Due to their high stability in UCB, circulating miRNAs are considered promising biomarkers for diagnosis and disease prognosis. Herein, we conduct a comprehensive review to summarize the roles of diverse UCB miRNAs from different perspectives, including UCB miRNA as biomarker for developmental projections and disease diagnosis, the relationship between maternal gestational status and neonatal UCB miRNA expression, the therapeutic function of exosomal UCB miRNA, miRNA expression profiles in UCB cell lineages. Taken together, miRNAs in UCB are very promising biomarkers for indicating physiological states, disease states, drug responses, development states, or health conditions, which can help in diagnosing, classifying, and predicting diseases, prognosis, or providing personalized treatment plans for patients.
Keywords
microRNA; umbilical cord blood; biomarker; neonatal diseases; neonatal development
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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