Detection of Human Papillomavirus (HPV) and Bovine Leukemia Virus (BLV) in Breast Cancer Patients from Northeastern Brazil

Zhilbely da Mota Nunes; Douglas de Lucena Silva; Igor Cordeiro Fernandes; Kamylla Conceição Gomes do Nascimento; André Luiz dos Santos Jesus; Niara Isis Pereira de Oliveira; Anderson Felix dos Santos; Sylvia Satomi Takeno Herrero; João Ricardo Gonçalves de Oliveira; Ivan Rodrigues de Carvalho Filho; Antonio Carlos de Freitas; Maria Tereza Cartaxo Muniz; Maria Angélica Ramos da Silva; Aldo Venuti; Eleonidas Moura Lima; Ana Pavla Almeida Diniz Gurgel

doi:10.20944/preprints202408.1024.v1

How to cite: da Mota Nunes, Z.; de Lucena Silva, D.; Cordeiro Fernandes, I.; Conceição Gomes do Nascimento, K.; Luiz dos Santos Jesus, A.; Isis Pereira de Oliveira, N.; Felix dos Santos, A.; Satomi Takeno Herrero, S.; Ricardo Gonçalves de Oliveira, J.; Rodrigues de Carvalho Filho, I.; Carlos de Freitas, A.; Tereza Cartaxo Muniz, M.; Ramos da Silva, M. A.; Venuti, A.; Moura Lima, E.; Almeida Diniz Gurgel, A. P. Detection of Human Papillomavirus (HPV) and Bovine Leukemia Virus (BLV) in Breast Cancer Patients from Northeastern Brazil. Preprints 2024, 2024081024. https://doi.org/10.20944/preprints202408.1024.v1 da Mota Nunes, Z.; de Lucena Silva, D.; Cordeiro Fernandes, I.; Conceição Gomes do Nascimento, K.; Luiz dos Santos Jesus, A.; Isis Pereira de Oliveira, N.; Felix dos Santos, A.; Satomi Takeno Herrero, S.; Ricardo Gonçalves de Oliveira, J.; Rodrigues de Carvalho Filho, I.; Carlos de Freitas, A.; Tereza Cartaxo Muniz, M.; Ramos da Silva, M. A.; Venuti, A.; Moura Lima, E.; Almeida Diniz Gurgel, A. P. Detection of Human Papillomavirus (HPV) and Bovine Leukemia Virus (BLV) in Breast Cancer Patients from Northeastern Brazil. Preprints 2024, 2024081024. https://doi.org/10.20944/preprints202408.1024.v1

Abstract

This study evaluated the presence of Human Papillomavirus (HPV) and Bovine Leukemia Virus (BLV) DNA in breast cancer (BC) samples from women in Northeastern Brazil. We analyzed 186 formalin-fixed, paraffin-embedded tissue block samples using PCR and qPCR to detect HPV and BLV DNA. BLV DNA was not detected in any BC patients. However, HPV DNA was found in 46.2\% of the BC samples: 44.6\% were positive for HPV16, 3.5\% for HPV31, and 2\% were coinfected with HPV16 and HPV31. Additionally, we found an association between HPV-positive BC and Ki-67 expression (P=0.03, OR=1.85; CI=1.02-3.34), as well as between HPV31-positive BC and mitotic index (P=0.047). Although BLV was not detected in BC patients from Northeastern Brazil, the association between HPV and cell proliferation markers warrants further investigation, as HPV may contribute to the aggressiveness of BC in these patients.

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Detection of Human Papillomavirus (HPV) and Bovine Leukemia Virus (BLV) in Breast Cancer Patients from Northeastern Brazil

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