Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study

How to cite: Eto, B.; Miantezila Basilua, J.; Outman, A.; Ndjip, R. C.; Alqahtani, A. S.; Bourhim, M.; Ibet, B.; Ramadam, I.; Torina, C.; Pagui, P.; Tchalkoutou, K.; Mahamat, N.; Cordier, J.; Gressier, B.; Desjeux, J.-F. Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study. Preprints 2024, 2024081121. https://doi.org/10.20944/preprints202408.1121.v1 Eto, B.; Miantezila Basilua, J.; Outman, A.; Ndjip, R. C.; Alqahtani, A. S.; Bourhim, M.; Ibet, B.; Ramadam, I.; Torina, C.; Pagui, P.; Tchalkoutou, K.; Mahamat, N.; Cordier, J.; Gressier, B.; Desjeux, J.-F. Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study. Preprints 2024, 2024081121. https://doi.org/10.20944/preprints202408.1121.v1

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MDPI and ACS Style

Eto, B.; Miantezila Basilua, J.; Outman, A.; Ndjip, R. C.; Alqahtani, A. S.; Bourhim, M.; Ibet, B.; Ramadam, I.; Torina, C.; Pagui, P.; Tchalkoutou, K.; Mahamat, N.; Cordier, J.; Gressier, B.; Desjeux, J.-F. Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study. Preprints 2024, 2024081121. https://doi.org/10.20944/preprints202408.1121.v1

APA Style

Eto, B., Miantezila Basilua, J., Outman, A., Ndjip, R. C., Alqahtani, A. S., Bourhim, M., Ibet, B., Ramadam, I., Torina, C., Pagui, P., Tchalkoutou, K., Mahamat, N., Cordier, J., Gressier, B., & Desjeux, J. F. (2024). Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study. Preprints. https://doi.org/10.20944/preprints202408.1121.v1

Chicago/Turabian Style

Eto, B., Bernard Gressier and Jehan-François Desjeux. 2024 "Exploring Boscia senegalensis-Derived Boscisucrophage: A Novel Dual SGLT1 and SGLT2 Inhibitor Enhancing Glycemic Control in Oral Drug-Resistant Type 2 Diabetes Patients: Insights from a Preliminary Observational Cohort Study" Preprints. https://doi.org/10.20944/preprints202408.1121.v1

Abstract

Background/Objectives: Boscia senegalensis (BS) Pers.) Lam. Ex Poir (Capparaceae), is an important local famine food plant in Africa and widely exploited by healers for its seeds in Sahelian region to reduce hyperglycaemia. Purpose: We studied the efficacy of commercial dosage form of BS namely Boscisucrophage (BSP) on type 2 diabetes (T2DM) patients with Oral antihyperglycemic drugs resistant. Study Design: Clinical benefits of BSP, were evaluated in multicentre cohort observational study on naïve patients (43) or diabetic patients resistant of oral antidiabetic drugs (289). All patients received capsules of the fixed dose containing 350 mg of BSP twice daily for 12 weeks and overactive control on vein blood sugar, glycosylated haemoglobin (HbA1c), urine glucose excretion (UGE), aspartate aminotransferase, alanine aminotransferase, creatinine, and clinical examination of functional symptoms. Results: In clinical study, BSP induced the reduction of glycaemia, HbA1c, and increase UGE, with removal of side effects functional symptoms of T2DM. Conclusions: In clinical studies, our findings lend support to use of BSP to reduce glycaemia, and HbA1c in T2DM patients with Oral antihyperglycemic drugs resistant without over adverse effects. BSP supressed clinical examination of functional symptoms.

Keywords

glycosylated haemoglobin; Oral antihyperglycemic drugs resistant; diabetes type 2; Boscisucrophage; gliflozin; dual SGLT1 and SGLT2 inhibition

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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