Version 1
: Received: 15 August 2024 / Approved: 16 August 2024 / Online: 20 August 2024 (04:01:00 CEST)
How to cite:
Tang, E.; Chen, N.; Li, J.; Ding, H.; Chen, H. Cognitive Functioning and Symptomatic Correlations during Audiovisual Multisensory Integration in Schizophrenia: A Systematic Review and Meta-Analysis. Preprints2024, 2024081256. https://doi.org/10.20944/preprints202408.1256.v1
Tang, E.; Chen, N.; Li, J.; Ding, H.; Chen, H. Cognitive Functioning and Symptomatic Correlations during Audiovisual Multisensory Integration in Schizophrenia: A Systematic Review and Meta-Analysis. Preprints 2024, 2024081256. https://doi.org/10.20944/preprints202408.1256.v1
Tang, E.; Chen, N.; Li, J.; Ding, H.; Chen, H. Cognitive Functioning and Symptomatic Correlations during Audiovisual Multisensory Integration in Schizophrenia: A Systematic Review and Meta-Analysis. Preprints2024, 2024081256. https://doi.org/10.20944/preprints202408.1256.v1
APA Style
Tang, E., Chen, N., Li, J., Ding, H., & Chen, H. (2024). Cognitive Functioning and Symptomatic Correlations during Audiovisual Multisensory Integration in Schizophrenia: A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202408.1256.v1
Chicago/Turabian Style
Tang, E., Hongwei Ding and Hui Chen. 2024 "Cognitive Functioning and Symptomatic Correlations during Audiovisual Multisensory Integration in Schizophrenia: A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202408.1256.v1
Abstract
Background: Multisensory integration (MSI) avoids cognitive overload, and the traditional all-or-nothing perspective for dysfunctional MSI in schizophrenia has been increasingly challenged. This study aimed to systematically review and meta-analyze extant evidence on audiovisual MSI in schizophrenia. Methods: We searched Web of Science, PubMed, PsycINFO and PsycARTICLES databases from inception until April 16th, 2024. Studies using appropriate audiovisual integration tasks to compare either behavioral or neural responses between schizophrenia individuals and healthy controls were included. Primary outcome measures included between-group differences (Hedge’s g) and symptomatic correlations (Fisher’s z) in three components of audiovisual integration tasks, including audiovisual processing, adaptation and integration. The multilevel random-effects models were used to address statistical dependency. Results: In total, 209 between-group and 116 correlational effect sizes were synthesized from 46 studies, representing 1,108 non-overlapped schizophrenia participants and 1,084 healthy controls. The overall dysfunctional audiovisual MSI in schizophrenia (g = -0.50, [95% CI, -0.64 to -0.37]) was primarily ascribed to the impaired audiovisual processing (g = -0.53, [95% CI, -0.71 to -0.35]) and adaptation (g = -0.71, [95% CI, -0.99 to -0.42]), rather than integration itself (g = -0.23, [95% CI, -0.56 to 0.11]). Pooled correlational effect size was extremely small (z = 0.16, [95% CI, 0.03 to 0.30]). Conclusions: Individuals with schizophrenia show dysfunctional multisensory processing and adaptation, but preserve a less impaired multisensory integration ability. Our findings provide implications for clinical interventions, as the relatively preserved audiovisual integration ability may serve as a possible avenue for cognitive training programs.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
