Article
Version 1
Preserved in Portico This version is not peer-reviewed
New Spectrophotometric Visible (VIS) Analysis to determine Sodium Valproate from Tablets
Version 1
: Received: 17 August 2024 / Approved: 19 August 2024 / Online: 19 August 2024 (14:27:53 CEST)
How to cite: GAVAT, C.-C. New Spectrophotometric Visible (VIS) Analysis to determine Sodium Valproate from Tablets. Preprints 2024, 2024081334. https://doi.org/10.20944/preprints202408.1334.v1 GAVAT, C.-C. New Spectrophotometric Visible (VIS) Analysis to determine Sodium Valproate from Tablets. Preprints 2024, 2024081334. https://doi.org/10.20944/preprints202408.1334.v1
Abstract
Sodium valproate is a established antiepileptic drug of first choice, primarily used to treat epilepsy, but also bipolar disorder and prevent migraine headaches. Valproate increases concentrations of gamma-aminobutyric acid in the brain, due to inhibition of enzymes responsible for the catabolism of gamma-aminobutyric acid. Main goal of this research consisted in the optimization and development for a new sensitive spectrophotometric quantitative analysis method of sodium valproate from tablets in the Visible field. Following the quantitative color reaction of sodium valproate with diazonium salt of alpha naphthylamine in alkaline medium, a light yellow azo dye was formed and spectrophotometrically analyzed at the wavelength of 386 nanometers. The amount of pure sodium valproate found on pharmaceutical extended-release tablet was 492.578 miligrams compared to the official declared pure amount of 500 miligrams on prolonged-release tablet. Amount found was assigned to a percentage content of 98.5156 percent pure sodium valproate in a pharmaceutical tablet. Mean average percentage error (deviation) from the officially stated value was about 1.4844 percent, which was included within normal limits, below five percent maximum limit allowed by European and Romanian Pharmacopoeias rules. Spectrophotometric method was subjected to the statistical validation procedure and was successfully validated.
Keywords
Sodium valproate; antiepileptic drug; spectrophotometric quantitative analysis method; light yellow azo dye; official declared pure amount; quantitative color reaction; statistical validation procedure
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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