Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Study on Minimum Inhibitory Concentration of Selected Antibacterials against Bacterial Isolates from Canine Pyometra

Version 1 : Received: 17 August 2024 / Approved: 19 August 2024 / Online: 19 August 2024 (12:12:54 CEST)

How to cite: Chhetri, A.; Paudel, M.; Gompo, T. R.; Thapaliya, S. Study on Minimum Inhibitory Concentration of Selected Antibacterials against Bacterial Isolates from Canine Pyometra. Preprints 2024, 2024081339. https://doi.org/10.20944/preprints202408.1339.v1 Chhetri, A.; Paudel, M.; Gompo, T. R.; Thapaliya, S. Study on Minimum Inhibitory Concentration of Selected Antibacterials against Bacterial Isolates from Canine Pyometra. Preprints 2024, 2024081339. https://doi.org/10.20944/preprints202408.1339.v1

Abstract

Minimum Inhibitory Concentration (MIC) measures the lowest concentration of antibiotic that inhibits in-vitro growth of microorganisms. Canine pyometra is a frequently occurring reproductive disorder where reliable antibiotics along with surgical excision of uterus predicts better prognosis. Scarce literature is available to facilitate proper antibiotic selection to avoid septicemia in clinical cases. The present study was conducted to determine sensitivity and potency of selected antibacterials based on MIC values against bacterial isolates obtained from Canine Pyometra in Kathmandu district, Nepal by Agar Dilution method. Isolates obtained from 63 intra-uterine samples after ovariohysterectomy were Enterococcus spp (n=41), Klebsiella spp. (n=7), Staphylococcus spp. (n=11) and Streptococcus spp. (n=4). Enrofloxacin and Amikacin were found highly sensitive (0% resistance) with a null hypothesis of resistance to all bacterial isolates and were significantly more potent than other antibacterials tested (p

Keywords

Minimum Inhibitory Concentration (MIC); Canine Pyometra; Antibiotic Sensitivity; Potency; Susceptibility; Bacterial Isolates; Agar Dilution Method; Antimicrobial Resistance (AMR)

Subject

Medicine and Pharmacology, Veterinary Medicine

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