Version 1
: Received: 20 August 2024 / Approved: 20 August 2024 / Online: 20 August 2024 (12:01:25 CEST)
How to cite:
Han, X.; Vollmer, D. Two Natural Product Compositions Improve Lifespan and Healthspan in Caenorhabditis Elegans by Targeting the Hallmarks of Aging. Preprints2024, 2024081403. https://doi.org/10.20944/preprints202408.1403.v1
Han, X.; Vollmer, D. Two Natural Product Compositions Improve Lifespan and Healthspan in Caenorhabditis Elegans by Targeting the Hallmarks of Aging. Preprints 2024, 2024081403. https://doi.org/10.20944/preprints202408.1403.v1
Han, X.; Vollmer, D. Two Natural Product Compositions Improve Lifespan and Healthspan in Caenorhabditis Elegans by Targeting the Hallmarks of Aging. Preprints2024, 2024081403. https://doi.org/10.20944/preprints202408.1403.v1
APA Style
Han, X., & Vollmer, D. (2024). Two Natural Product Compositions Improve Lifespan and Healthspan in Caenorhabditis Elegans by Targeting the Hallmarks of Aging. Preprints. https://doi.org/10.20944/preprints202408.1403.v1
Chicago/Turabian Style
Han, X. and David Vollmer. 2024 "Two Natural Product Compositions Improve Lifespan and Healthspan in Caenorhabditis Elegans by Targeting the Hallmarks of Aging" Preprints. https://doi.org/10.20944/preprints202408.1403.v1
Abstract
Aging has been increasingly recognized as a global health burden. Current aging research suggests that preventative strategies may increase both lifespan and healthspan. Many natural compounds or natural products have demonstrated promising antiaging benefits and gained popularity in aging research. The present study evaluated two compositions comprised of nicotinamide mononucleotide, quercetin, alpha ketoglutarate, white button mushroom extract (standardized to spermidine), Transfer Factor (extracts from cow colostrum and chicken egg yolk) with or without milk thistle fruit extract (standardized to silybin) and apigenin for their antiaging effect in Caenorhabditis elegans. The active ingredients included in the two compositions were screened for their senolytic effects on cell viability of irradiated human umbilical vein endothelial cells. To further explore their potential molecular mechanisms of action, the two compositions were also tested for their binding activity to human sirtuin enzymes, and TF on natural killer cell activities in human peripheral blood mononuclear cells from both young and old donors. Both compositions significantly increased the lifespan and healthspan of C. elegans. Both compositions demonstrated significant dose-dependent inhibitory effect on several sirtuins. When treated with Transfer Factor, both younger and older human peripheral blood mononuclear cells bolstered natural killer cell activity. The present study suggested that these two compositions significantly improved both lifespan and healthspan of Caenorhabditis elegans likely by modulating sirtuin activity and rejuvenating senescent immune cells..
Keywords
lifespan; healthspan; transfer factor; Nicotinamide mononucleotide; NMN; Spermidine
Subject
Biology and Life Sciences, Aging
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
