Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam

Nguyen Van Diep; Nguyen Van Duc; Nguyen Thi Ngoc; Dang Xuan Vu; Tran Ngoc Tiep; Viet Dung Nguyen; Thi Tam Than; Dustin Maydaniuk; Kalhari Goonewardene; Aruna Ambagala; Van Phan Le

doi:10.20944/preprints202408.1438.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202408.1438.v1 (registering DOI)

Preprint Article Version 1 This version is not peer-reviewed

Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam

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Version 1 : Received: 19 August 2024 / Approved: 20 August 2024 / Online: 20 August 2024 (13:24:06 CEST)

How to cite: Diep, N. V.; Duc, N. V.; Ngoc, N. T.; Vu, D. X.; Tiep, T. N.; Nguyen, V. D.; Than, T. T.; Maydaniuk, D.; Goonewardene, K.; Ambagala, A.; Le, V. P. Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam. Preprints 2024, 2024081438. https://doi.org/10.20944/preprints202408.1438.v1 Diep, N. V.; Duc, N. V.; Ngoc, N. T.; Vu, D. X.; Tiep, T. N.; Nguyen, V. D.; Than, T. T.; Maydaniuk, D.; Goonewardene, K.; Ambagala, A.; Le, V. P. Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam. Preprints 2024, 2024081438. https://doi.org/10.20944/preprints202408.1438.v1

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MDPI and ACS Style

Diep, N. V.; Duc, N. V.; Ngoc, N. T.; Vu, D. X.; Tiep, T. N.; Nguyen, V. D.; Than, T. T.; Maydaniuk, D.; Goonewardene, K.; Ambagala, A.; Le, V. P. Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam. Preprints 2024, 2024081438. https://doi.org/10.20944/preprints202408.1438.v1

APA Style

Diep, N. V., Duc, N. V., Ngoc, N. T., Vu, D. X., Tiep, T. N., Nguyen, V. D., Than, T. T., Maydaniuk, D., Goonewardene, K., Ambagala, A., & Le, V. P. (2024). Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam. Preprints. https://doi.org/10.20944/preprints202408.1438.v1

Chicago/Turabian Style

Diep, N. V., Aruna Ambagala and Van Phan Le. 2024 "Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam" Preprints. https://doi.org/10.20944/preprints202408.1438.v1

Abstract

African swine fever virus (ASFV) continues to spread globally causing severe economic losses to the pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF, to control the ongoing ASF outbreaks. In 2023, newly emerging highly virulent recombinant ASFV viruses containing genetic elements from both ASFV p72 genotype I and II (rASFV I/II) strains were reported from Northern Vietnam. This study evaluated if the two vaccine strains were able to protect the pigs against the emerging rASFV I/II strain VNUA/rASFV/TN1/23. Pigs vaccinated with ASFV-G-ΔMGF or ASFV-G-ΔI177L, when challenged with rASFV I/II, succumbed to the infection, or developed signs of chronic ASF. The findings from this study show that both vaccine strains that are licensed and used in Vietnam, are unlikely to protect pigs from the emerging highly virulent rASFV I/II strains. This complicates the ongoing efforts to control ASF in Asia and globally and emphasizes the urgent need for a novel vaccine that can effectively protect pigs from the rASFV I/II strains.

Keywords

African swine fever; live-attenuated; vaccine; emerging; recombinant genotype I/II; ASFV-G-ΔMGF; ASFV-G-ΔI177L

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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