Version 1
: Received: 20 August 2024 / Approved: 21 August 2024 / Online: 22 August 2024 (06:39:50 CEST)
How to cite:
Doherty, G.; Naylor, M.; Draper, H.; Fletcher, D. M.; Rigby, A.; Adedipe, T.; Guinn, B.-A. Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. Preprints2024, 2024081558. https://doi.org/10.20944/preprints202408.1558.v1
Doherty, G.; Naylor, M.; Draper, H.; Fletcher, D. M.; Rigby, A.; Adedipe, T.; Guinn, B.-A. Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. Preprints 2024, 2024081558. https://doi.org/10.20944/preprints202408.1558.v1
Doherty, G.; Naylor, M.; Draper, H.; Fletcher, D. M.; Rigby, A.; Adedipe, T.; Guinn, B.-A. Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. Preprints2024, 2024081558. https://doi.org/10.20944/preprints202408.1558.v1
APA Style
Doherty, G., Naylor, M., Draper, H., Fletcher, D. M., Rigby, A., Adedipe, T., & Guinn, B. A. (2024). Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202408.1558.v1
Chicago/Turabian Style
Doherty, G., Tolu Adedipe and Barbara-ann Guinn. 2024 "Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202408.1558.v1
Abstract
Ovarian torsion (OT) is a rare gynaecological emergency that requires a prompt diagnosis for optimal patient management. To determine whether there were any biomarkers suitable for the non-invasive detection of OT, two independent reviewers performed systematic searches of five literature databases following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Full-texts of 24 selected articles were assessed for risk of bias and quality assurance using a modified Newcastle-Ottawa Scale (NOS). 15 articles described studies on animals and all described serum biomarkers comparing results between OT versus a sham operation, a control group or readings before and after OT. Ischaemia modified albumin (IMA), serum D-dimer (s-DD), heat shock protein-70 (hsp-70), Pentraxin-3 (PTX-3) and c-reactive protein (CRP) showed the most promise, each with p-values for the difference between groups achieving ≤0.001. In studies of humans, the biomarkers ranged from 16.4-92.3% sensitivity and 77-100% specificity. The most promising biomarkers for the early prediction of OT in patients included s-DD, interleukin-6 (IL-6), IMA and tumour necrosis factor-alpha (TNF-. IL-6 had the highest sensitivity of any biomarker identified in this review and was raised in all 13 patients with proven OT, with values of ≥10.2pg/ml, indicative of a 16 times higher risk of having OT. Signal peptide, CUB domain and EGF like domain containing 1 (SCUBE1) had a high specificity at 93.3%, second only to s-DD and a positive likelihood ratio (LR)>10. IMA was the only other biomarker that also had a positive LR>10, making it a promising diagnostic biomarker. The studies identified by this systematic literature review each analysed small patient groups but IMA, DD and SCUBE1 nevertheless showed promise as serum biomarkers with a pooled LR>10. However, further well-designed studies are needed to identify and evaluate individual markers, or diagnostic panels to help clinicians manage this important, organ-threatening condition.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
