Version 1
: Received: 22 August 2024 / Approved: 23 August 2024 / Online: 25 August 2024 (06:38:39 CEST)
How to cite:
Tsolakidis, D.; Zouzoulas, D.; Tzitzis, P.; Sofianou, I.; Theodoulidis, V.; Chatzistamatiou, K.; Karalis, T.; Topalidou, M.; Timotheadou, E.; Grimbizis, G. The Role of Douglasectomy Instead of Random Biopsies in the Surgical Treatment of Presumed FIGO Stage I Ovarian Cancer. Preprints2024, 2024081700. https://doi.org/10.20944/preprints202408.1700.v1
Tsolakidis, D.; Zouzoulas, D.; Tzitzis, P.; Sofianou, I.; Theodoulidis, V.; Chatzistamatiou, K.; Karalis, T.; Topalidou, M.; Timotheadou, E.; Grimbizis, G. The Role of Douglasectomy Instead of Random Biopsies in the Surgical Treatment of Presumed FIGO Stage I Ovarian Cancer. Preprints 2024, 2024081700. https://doi.org/10.20944/preprints202408.1700.v1
Tsolakidis, D.; Zouzoulas, D.; Tzitzis, P.; Sofianou, I.; Theodoulidis, V.; Chatzistamatiou, K.; Karalis, T.; Topalidou, M.; Timotheadou, E.; Grimbizis, G. The Role of Douglasectomy Instead of Random Biopsies in the Surgical Treatment of Presumed FIGO Stage I Ovarian Cancer. Preprints2024, 2024081700. https://doi.org/10.20944/preprints202408.1700.v1
APA Style
Tsolakidis, D., Zouzoulas, D., Tzitzis, P., Sofianou, I., Theodoulidis, V., Chatzistamatiou, K., Karalis, T., Topalidou, M., Timotheadou, E., & Grimbizis, G. (2024). The Role of Douglasectomy Instead of Random Biopsies in the Surgical Treatment of Presumed FIGO Stage I Ovarian Cancer. Preprints. https://doi.org/10.20944/preprints202408.1700.v1
Chicago/Turabian Style
Tsolakidis, D., Eleni Timotheadou and Grigoris Grimbizis. 2024 "The Role of Douglasectomy Instead of Random Biopsies in the Surgical Treatment of Presumed FIGO Stage I Ovarian Cancer" Preprints. https://doi.org/10.20944/preprints202408.1700.v1
Abstract
Background/Objectives: Douglasectomy is defined as the removal of the pelvic peritoneum of the entire pouch of Douglas. In presumed FIGO Stage I ovarian cancer isolated microscopic cancer cells might disseminate from the ovaries to their neighboring pelvic peritoneum. However, simple hysterectomy with bilateral salpingo-oophorectomy and a staging procedure is the standard of care. This study aims to investigate the safety and feasibility of douglasectomy, compared to random pelvic biopsies, and its on the survival of patients with early ovarian cancer; Methods: We retrospectively analyzed the records of patients with presumed FIGO Stage I ovarian cancer that underwent surgery in the 1st Department of Obstetrics – Gynecology Clinic from 2012 – 2022. Patient characteristics, oncological and follow-up information were collected.; Results: 88 patients were categorized into two groups: Group A (27 patients) with douglasectomy and Group B (61 patients) with random biopsies. There was no statistically significant difference in age, BMI, comorbidities, intraoperative blood loss and ICU admittance between the two groups. On the other hand, patients with en-block hysterectomy-douglasectomy had a statistically significant higher pre-operative CA-125 values, surgery duration, rate of postoperative complications and hospital stay. Concerning survival rates, there was a statistically significant difference in dis-ease-free survival (p=0.033), but no difference was observed in overall survival (p=0.66); Conclu-sions: En-block removal of the pelvic peritoneum of the entire pouch of Douglas with the uterus is a safe and feasible technique during surgery for early ovarian cancer, which leads to improved disease-free survival and local control.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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