New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies

Somaia S. Abd El-Karim; Manal M. Anwar; Yasmin M. Syam; Hassan M. Awad; Asmaa Negm El-Dein; Mohamed K. El-Ashrey; Hamad M. Alkahtani; Sameh H Abdelwahed

doi:10.20944/preprints202408.1792.v2

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preprints.org > chemistry and materials science > medicinal chemistry > doi: 10.20944/preprints202408.1792.v2

Preprint Article Version 2 This version is not peer-reviewed

New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies

Somaia S. Abd El-Karim

Version 1 : Received: 25 August 2024 / Approved: 26 August 2024 / Online: 26 August 2024 (08:28:09 CEST)
Version 2 : Received: 22 October 2024 / Approved: 23 October 2024 / Online: 24 October 2024 (08:21:46 CEST)

How to cite: Abd El-Karim, S. S.; Anwar, M. M.; Syam, Y. M.; Awad, H. M.; El-Dein, A. N.; El-Ashrey, M. K.; Alkahtani, H. M.; Abdelwahed, S. H. New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies. Preprints 2024, 2024081792. https://doi.org/10.20944/preprints202408.1792.v2 Abd El-Karim, S. S.; Anwar, M. M.; Syam, Y. M.; Awad, H. M.; El-Dein, A. N.; El-Ashrey, M. K.; Alkahtani, H. M.; Abdelwahed, S. H. New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies. Preprints 2024, 2024081792. https://doi.org/10.20944/preprints202408.1792.v2

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MDPI and ACS Style

Abd El-Karim, S. S.; Anwar, M. M.; Syam, Y. M.; Awad, H. M.; El-Dein, A. N.; El-Ashrey, M. K.; Alkahtani, H. M.; Abdelwahed, S. H. New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies. Preprints 2024, 2024081792. https://doi.org/10.20944/preprints202408.1792.v2

APA Style

Abd El-Karim, S. S., Anwar, M. M., Syam, Y. M., Awad, H. M., El-Dein, A. N., El-Ashrey, M. K., Alkahtani, H. M., & Abdelwahed, S. H. (2024). New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies. Preprints. https://doi.org/10.20944/preprints202408.1792.v2

Chicago/Turabian Style

Abd El-Karim, S. S., Hamad M. Alkahtani and Sameh H Abdelwahed. 2024 "New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-Inflammatory, DNA Gyrase B Inhibition and In Silico Studies" Preprints. https://doi.org/10.20944/preprints202408.1792.v2

Abstract

The alarming rise of antibiotic resistance has made it imperative to find novel antimicrobial medications. This study reports the design and synthesis of new molecules based on benzofu-ran-pyrazole scaffolds hybridized with various N/O heterocycles using the molecular hybridiza-tion process. The newly synthesized candidates were confirmed using micro-analytical and spectral analyses, and their antimicrobial characteristics were assessed against different bacterial and fungal isolates in comparison with novobiocin and clotrimazole as antibacterial and anti-fungal standards, respectively. In addition, the new compounds were further evaluated as in vitro antioxidants and anti-inflammatory congeners. The most promising broad spectrum antimicrobial compounds 9, 10 with values ranging from 2.50-20.60 μg/mL were further examined as E. coli DNA gyrase B enzyme suppressors using novobiocin as a reference drug. In silico computational and ADMET studies were carried out for the most active compounds.

Keywords

Benzofuran-pyrazole scaffold; antimicrobial activity; antioxidant; in vitro anti-inflammatory DNA gyrase enzyme; computational studies

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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