Version 1
: Received: 25 August 2024 / Approved: 26 August 2024 / Online: 26 August 2024 (12:12:01 CEST)
How to cite:
Maeda, S.; Kai, K.; Kawasaki, K.; Tanaka, T.; Ide, T.; Noshiro, H. Analysis of CD1a-Positive Dendritic Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. Preprints2024, 2024081808. https://doi.org/10.20944/preprints202408.1808.v1
Maeda, S.; Kai, K.; Kawasaki, K.; Tanaka, T.; Ide, T.; Noshiro, H. Analysis of CD1a-Positive Dendritic Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. Preprints 2024, 2024081808. https://doi.org/10.20944/preprints202408.1808.v1
Maeda, S.; Kai, K.; Kawasaki, K.; Tanaka, T.; Ide, T.; Noshiro, H. Analysis of CD1a-Positive Dendritic Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. Preprints2024, 2024081808. https://doi.org/10.20944/preprints202408.1808.v1
APA Style
Maeda, S., Kai, K., Kawasaki, K., Tanaka, T., Ide, T., & Noshiro, H. (2024). Analysis of CD1a-Positive Dendritic Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer. Preprints. https://doi.org/10.20944/preprints202408.1808.v1
Chicago/Turabian Style
Maeda, S., Takao Ide and Hirokazu Noshiro. 2024 "Analysis of CD1a-Positive Dendritic Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer" Preprints. https://doi.org/10.20944/preprints202408.1808.v1
Abstract
Dendritic cells (DCs) are known as major antigen-presenting cells, and lymph nodes (LNs) play an important role in the DC-mediated immune response. This study focused on infiltration of CD1a-positive DCs (CD1a-DCs) in regional LNs in 70 cases of gallbladder cancer (GBC). The results showed that LNs infiltration by CD1a-DCs was associated with unfavorable clinical outcomes in patients with GBC in univariate analyses, but all cases categorized as CD1a-DCs high group at regional LNs had nodal metastasis. Therefore, LNs infiltration by CD1a-DCs was not an independent prognostic factor identified by multivariate analyses. The subgroup analyses in cases with LN metastasis group (n = 32), significant impact of CD1a-DCs infiltration into metastatic LNs was not observed. In contrast, CD1a-DCs infiltration into primary tumor had a significant impact on surgical outcomes. As the results of previous reports that focused on CD1a-DCs infiltration in regional LNs of other organs were varied, the role and significance of CD1a-DCs infiltration in regional LNs may be different according to the tumor histology or primary site. Accumulation of further studies is needed to clarify the role and significance of CD1a-DCs infiltration into regional LNs of solid cancers.
Keywords
dendritic cell; CD1a; S100; lymph node; gallbladder cancer
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
