Version 1
: Received: 26 August 2024 / Approved: 26 August 2024 / Online: 26 August 2024 (09:33:09 CEST)
How to cite:
Escobar Moreno, J. D.; Fajardo Castiblanco, J. L.; Riaño Rodriguez, L. C.; Barrios Ospina, P. M.; Zabala Bello, C. A.; Muñoz Roa, E. N.; Rivera Escobar, H. M. miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma. Preprints2024, 2024081819. https://doi.org/10.20944/preprints202408.1819.v1
Escobar Moreno, J. D.; Fajardo Castiblanco, J. L.; Riaño Rodriguez, L. C.; Barrios Ospina, P. M.; Zabala Bello, C. A.; Muñoz Roa, E. N.; Rivera Escobar, H. M. miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma. Preprints 2024, 2024081819. https://doi.org/10.20944/preprints202408.1819.v1
Escobar Moreno, J. D.; Fajardo Castiblanco, J. L.; Riaño Rodriguez, L. C.; Barrios Ospina, P. M.; Zabala Bello, C. A.; Muñoz Roa, E. N.; Rivera Escobar, H. M. miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma. Preprints2024, 2024081819. https://doi.org/10.20944/preprints202408.1819.v1
APA Style
Escobar Moreno, J. D., Fajardo Castiblanco, J. L., Riaño Rodriguez, L. C., Barrios Ospina, P. M., Zabala Bello, C. A., Muñoz Roa, E. N., & Rivera Escobar, H. M. (2024). miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma. Preprints. https://doi.org/10.20944/preprints202408.1819.v1
Chicago/Turabian Style
Escobar Moreno, J. D., Esther Natalia Muñoz Roa and Hernan Mauricio Rivera Escobar. 2024 "miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma" Preprints. https://doi.org/10.20944/preprints202408.1819.v1
Abstract
Reactive oxygen species (ROS) are intermediates in oxidation-reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment and microRNAs expression in melanoma is not fully understood. The aim of this review is to analyze the involvement of miRNAs in the modulation of signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma and therefore a potential footprint poorly documented.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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