Version 1
: Received: 27 August 2024 / Approved: 27 August 2024 / Online: 27 August 2024 (18:42:05 CEST)
How to cite:
Tasheva, D. N.; Mihaylova, V. M. Rel-(2R, 3S)-2-((Diphenylmethylene)amino)-5-Oxo-5-Phenyl-3-(Thiophen-2-Yl)pentanenitrile. Preprints2024, 2024081953. https://doi.org/10.20944/preprints202408.1953.v1
Tasheva, D. N.; Mihaylova, V. M. Rel-(2R, 3S)-2-((Diphenylmethylene)amino)-5-Oxo-5-Phenyl-3-(Thiophen-2-Yl)pentanenitrile. Preprints 2024, 2024081953. https://doi.org/10.20944/preprints202408.1953.v1
Tasheva, D. N.; Mihaylova, V. M. Rel-(2R, 3S)-2-((Diphenylmethylene)amino)-5-Oxo-5-Phenyl-3-(Thiophen-2-Yl)pentanenitrile. Preprints2024, 2024081953. https://doi.org/10.20944/preprints202408.1953.v1
APA Style
Tasheva, D. N., & Mihaylova, V. M. (2024). Rel-(2R, 3S)-2-((Diphenylmethylene)amino)-5-Oxo-5-Phenyl-3-(Thiophen-2-Yl)pentanenitrile. Preprints. https://doi.org/10.20944/preprints202408.1953.v1
Chicago/Turabian Style
Tasheva, D. N. and Vesela Mihaylova Mihaylova. 2024 "Rel-(2R, 3S)-2-((Diphenylmethylene)amino)-5-Oxo-5-Phenyl-3-(Thiophen-2-Yl)pentanenitrile" Preprints. https://doi.org/10.20944/preprints202408.1953.v1
Abstract
The reaction of 2-((diphenylmethylene)amino)acetonitrile with (E)-1-phenyl-3-(thiophen-2-yl)prop-2-en-1-one was performed by using 33% NaOH in CH3CN for 30 min at 0°C. The main product - rel-(2R,3S)-2-((diphenylmethylene)amino)-5-oxo-5-phenyl-3-(thiophen-2-yl)pentanenitrile was isolated and characterized by IR, 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS).
Keywords
2-((diphenylmethylene)amino)acetonitrile; Michael addition; non-proteinogenic aminoacids
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
