Preprint Review Version 1 This version is not peer-reviewed

AgNPs: An Adaptive Methodology in Malignant Growth Treatment, Disclosing Upgraded Radiotherapy and Beyond

Version 1 : Received: 27 August 2024 / Approved: 27 August 2024 / Online: 27 August 2024 (16:29:38 CEST)

How to cite: ALMAYAHI, B. AgNPs: An Adaptive Methodology in Malignant Growth Treatment, Disclosing Upgraded Radiotherapy and Beyond. Preprints 2024, 2024081965. https://doi.org/10.20944/preprints202408.1965.v1 ALMAYAHI, B. AgNPs: An Adaptive Methodology in Malignant Growth Treatment, Disclosing Upgraded Radiotherapy and Beyond. Preprints 2024, 2024081965. https://doi.org/10.20944/preprints202408.1965.v1

Abstract

Silver nanoparticles (AgNPs) have arisen as promising specialists in malignant growth treatment, especially in further developing radiotherapy results. In vitro examinations feature AgNPs' capacity to increment radiosensitivity in disease cell lines, prompting uplifted cell demise and decreased clonogenic endurance. Outstandingly, AgNPs display insignificant poisonousness to ordinary cells, recommending potential for specific focusing of disease cells during radiotherapy. The blend of AgNPs with cisplatin shows huge cytotoxicity and oxidative pressure, particularly in tumoral cells, underscoring the requirement for additional investigation of this therapeutic methodology. AgNPs likewise show guarantee in prompting oxidative pressure in pancreatic disease cells, recommending an expected application in pancreatic malignant growth treatment. In co-openness situations, AgNPs, when joined with cadmium, prompt metabolic variation, showing compromised cell safeguard systems. Moreover, AgNPs display potential in tweaking ABC carrier action, offering a procedure to defeat multidrug obstruction in disease cells. While featuring the significant capability of AgNPs in disease treatment, the rundown highlights the need for continuous exploration to clarify their components, well-being profiles, and clinical applications. Combining AgNPs with radiotherapy presents a promising road, tending to limits in ordinary disease therapies and underlining their multifunctionality in forming the eventual fate of malignant growth therapeutics.

Keywords

Ag nanoparticles; growth cell; radiotherapy; in vitro; characterization

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

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