PreprintReviewVersion 1This version is not peer-reviewed
Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes
Version 1
: Received: 26 August 2024 / Approved: 27 August 2024 / Online: 28 August 2024 (10:27:45 CEST)
How to cite:
Lev, L.; Petersen, K.; Roberts, J. L.; Kupferer, K.; Werder, S. Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes. Preprints2024, 2024082021. https://doi.org/10.20944/preprints202408.2021.v1
Lev, L.; Petersen, K.; Roberts, J. L.; Kupferer, K.; Werder, S. Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes. Preprints 2024, 2024082021. https://doi.org/10.20944/preprints202408.2021.v1
Lev, L.; Petersen, K.; Roberts, J. L.; Kupferer, K.; Werder, S. Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes. Preprints2024, 2024082021. https://doi.org/10.20944/preprints202408.2021.v1
APA Style
Lev, L., Petersen, K., Roberts, J. L., Kupferer, K., & Werder, S. (2024). Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes. Preprints. https://doi.org/10.20944/preprints202408.2021.v1
Chicago/Turabian Style
Lev, L., Kevin Kupferer and Steven Werder. 2024 "Interactions Between Folic Acid Supplementation and Vitamin B12 Deficiency in Pregnant Women with Celiac Disease and Associated Maternal/Fetal Outcomes" Preprints. https://doi.org/10.20944/preprints202408.2021.v1
Abstract
Celiac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten, affecting approximately 1% of the global population and two million Americans. An increasing number of studies have identified a link between celiac disease and adverse maternal and fetal outcomes during pregnancy and after birth. Additionally, both celiac disease and pregnancy are associated with an increased risk for nutrient deficiencies, specifically vitamin B12 and folate. Deficiencies in these key nutrients are linked with several negative maternal and fetal health outcomes including preeclampsia, gestational diabetes, spontaneous abortion/miscarriage, preterm birth, NTDs, Intrauterine Growth Restriction, and low gestational age and birthweight. This review examines the current literature related to the folate trap and vitamin B12 deficiency in patients with celiac disease and pregnant women independently, and to provide rationale for future research to explore the correlation between the folate to B12 ratio in pregnant woman with celiac disease.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
