PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk
Version 1
: Received: 27 August 2024 / Approved: 28 August 2024 / Online: 29 August 2024 (06:10:03 CEST)
How to cite:
Scherer, M.; Soldevila-Boixader, L.; Yildiz, I.; Furrer, P. R.; Beeler, S.; Wirth, S. H.; Viehöfer, A.; Uckay, I. Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk. Preprints2024, 2024082080. https://doi.org/10.20944/preprints202408.2080.v1
Scherer, M.; Soldevila-Boixader, L.; Yildiz, I.; Furrer, P. R.; Beeler, S.; Wirth, S. H.; Viehöfer, A.; Uckay, I. Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk. Preprints 2024, 2024082080. https://doi.org/10.20944/preprints202408.2080.v1
Scherer, M.; Soldevila-Boixader, L.; Yildiz, I.; Furrer, P. R.; Beeler, S.; Wirth, S. H.; Viehöfer, A.; Uckay, I. Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk. Preprints2024, 2024082080. https://doi.org/10.20944/preprints202408.2080.v1
APA Style
Scherer, M., Soldevila-Boixader, L., Yildiz, I., Furrer, P. R., Beeler, S., Wirth, S. H., Viehöfer, A., & Uckay, I. (2024). Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk. Preprints. https://doi.org/10.20944/preprints202408.2080.v1
Chicago/Turabian Style
Scherer, M., Arnd Viehöfer and Ilker Uckay. 2024 "Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk" Preprints. https://doi.org/10.20944/preprints202408.2080.v1
Abstract
Whereas there is an increasing number of scientific publications investigating the optimal anti-biotic treatment for diabetic foot infections, we are lacking corresponding data in the adult non-diabetic (postsurgical) foot infection population. We therefore established one of the largest single-center databases on this topic and retrospectively investigate failures of a combined sur-gical and antibiotic therapy for surgical site foot infections. Overall, 17.4% of the episodes expe-rienced any therapeutic failures; especially among the infected ankle prostheses. In contrast, neither the age, the biological sex, pathogens, the duration of post-debridement antibiotic treatment, the number of surgical debridement, or the use of negative-pressure wound care could alter the failure risk. In multivariate logistic regression analyses, the duration of postsur-gical antibiotic use was completely indifferent (as a continuous variable with odds ratio 1.0, 95% confidence interval 0.96-1.03), or when stratified into inter-tertiary groups. Our results poten-tially enable shorter applications of systemic antibiotics in favor of a better stewardship in the non-diabetic adult population. Consecutive prospective-randomized trials are under way to identify eligible patient populations for a potentially shorter durations in surgical site infections after elective foot and ankle surgery.
Keywords
adult foot and ankle surgery; infection; surgical site infections; surgical debridement; duration of antibiotic treatment; treatment failures; total ankle prostheses
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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