Version 1
: Received: 30 August 2024 / Approved: 1 September 2024 / Online: 2 September 2024 (12:10:31 CEST)
How to cite:
Herman-Antosiewicz, A.; Gimła, M. Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks. Preprints2024, 2024090022. https://doi.org/10.20944/preprints202409.0022.v1
Herman-Antosiewicz, A.; Gimła, M. Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks. Preprints 2024, 2024090022. https://doi.org/10.20944/preprints202409.0022.v1
Herman-Antosiewicz, A.; Gimła, M. Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks. Preprints2024, 2024090022. https://doi.org/10.20944/preprints202409.0022.v1
APA Style
Herman-Antosiewicz, A., & Gimła, M. (2024). Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks. Preprints. https://doi.org/10.20944/preprints202409.0022.v1
Chicago/Turabian Style
Herman-Antosiewicz, A. and Mariola Gimła. 2024 "Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks" Preprints. https://doi.org/10.20944/preprints202409.0022.v1
Abstract
Cancer, a complex group of diseases marked by uncontrolled cell growth and invasive behavior, is characterized by distinct hallmarks acquired during tumor development. These hallmarks, first proposed by Douglas Hanahan and Robert Weinberg in 2000, provide a framework for un-derstanding cancer's complexity. Targeting them is a key strategy in cancer therapy. It includes inhibiting abnormal signaling, reactivating growth suppressors, preventing invasion and me-tastasis, inhibiting angiogenesis, limiting replicative immortality, modulating the immune sys-tem, inducing apoptosis, addressing genome instability, and regulating cellular energetics.
Usnic acid (UA) is a natural compound found in lichens that has been explored as a cytotoxic agent against cancer cells of different origins. Although the exact mechanisms remain incom-pletely understood, UA presents a promising compound for therapeutic intervention. Under-standing its impact on cancer hallmarks provides valuable insights into the potential of UA in developing targeted and multifaceted cancer therapies.
This article explores UA activity in the context of disrupting hallmarks in cancer cells of different origins based on articles that emphasize the molecular mechanisms of this activity.
Keywords
Usnic Acid (UA); antiproliferative activity; cancer treatment; cancer hallmarks; lichens
Subject
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
