Version 1
: Received: 3 September 2024 / Approved: 3 September 2024 / Online: 3 September 2024 (23:28:39 CEST)
How to cite:
Kowitt, C.; Zhang, Q. Interleukin-33 and Obesity-Related inflammation and Cancer. Preprints2024, 2024090252. https://doi.org/10.20944/preprints202409.0252.v1
Kowitt, C.; Zhang, Q. Interleukin-33 and Obesity-Related inflammation and Cancer. Preprints 2024, 2024090252. https://doi.org/10.20944/preprints202409.0252.v1
Kowitt, C.; Zhang, Q. Interleukin-33 and Obesity-Related inflammation and Cancer. Preprints2024, 2024090252. https://doi.org/10.20944/preprints202409.0252.v1
APA Style
Kowitt, C., & Zhang, Q. (2024). Interleukin-33 and Obesity-Related inflammation and Cancer. Preprints. https://doi.org/10.20944/preprints202409.0252.v1
Chicago/Turabian Style
Kowitt, C. and Qiuyang Zhang. 2024 "Interleukin-33 and Obesity-Related inflammation and Cancer" Preprints. https://doi.org/10.20944/preprints202409.0252.v1
Abstract
Obesity and chronic inflammation are well-known risk factors for cancer. Interleukin-33 (IL-33) functions in inflammatory diseases, particularly those related to obesity and cancer. However, the correlation and molecular mechanisms linking IL-33, obesity, and cancer remain unclear. IL-33 is a nuclear cytokine released as an alarm signal when cells are damaged or stressed. It is expressed in epithelial, endothelial, and fibroblast-like cells during normal conditions and in-flammation. When IL-33 is present, immune cells expressing the IL-1RL1/ST2 receptor are alerted in response to tissue damage or cell injury. Research on IL-33 and its correlation with obesity has revealed improvements in inflammatory and metabolic changes associated with obesity. IL-33 can have both pro-tumorigenic and antitumorigenic effects, depending on the cellular content, in-flammatory environment, expression levels, and bioactivity of IL-33. This review will discuss the various functions of IL-33 in obesity-driven inflammation and cancers and how they intersect.
Keywords
IL-33; ST2; Immune Cells; Inflammation; Obesity; Cancer
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
