“Beyond the Knife” - Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology

Santosh Guru; Fred C Lam; Yusuke S Hori; Deyaaldeen AbuReesh; Armine Tayag; Sara C Emrich; Louisa Ustrzynski; David J Park; Steven D Chang

doi:10.20944/preprints202409.0258.v1

Preprint Review Version 1 This version is not peer-reviewed

Version 1 : Received: 2 September 2024 / Approved: 3 September 2024 / Online: 3 September 2024 (20:00:34 CEST)

Current standard of care for brain tumor management includes maximal safe surgical resection followed by concurrent chemotherapy and radiation therapy. Recent advances in image-guided surgical techniques have enhanced the precision of tumor resections, yet there remains a critical need for innovative technologies to further improve patient outcomes. The emerging use of theranostic technologies to improve surgical outcomes can further augment the efficacy of adjuvant radiosurgery/radiotherapy and systemic therapies. Stanford Neurosurgery is a leader in the field of translational neuro-oncology. In this review, we provide an expert view of how theranostics can be integrated into future therapeutic treatment algorithms to help improve survival for patients with brain tumors.

brain tumors; gliomas; radiosurgery; Cyberknife; nanotechnology; blood-brain barrier; chemotherapy; neurosurgery; neuro-oncology; image-guided surgery; fluorescence-guided surgery

Medicine and Pharmacology, Neuroscience and Neurology

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“Beyond the Knife” - Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology

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