Version 1
: Received: 3 September 2024 / Approved: 4 September 2024 / Online: 4 September 2024 (08:32:32 CEST)
How to cite:
ferrari, I. Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles. Preprints2024, 2024090307. https://doi.org/10.20944/preprints202409.0307.v1
ferrari, I. Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles. Preprints 2024, 2024090307. https://doi.org/10.20944/preprints202409.0307.v1
ferrari, I. Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles. Preprints2024, 2024090307. https://doi.org/10.20944/preprints202409.0307.v1
APA Style
ferrari, I. (2024). Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles. Preprints. https://doi.org/10.20944/preprints202409.0307.v1
Chicago/Turabian Style
ferrari, I. 2024 "Exploring Glucocorticoid Safety: Insights from pKCSM Predictions on Tolerability and Toxicity Profiles" Preprints. https://doi.org/10.20944/preprints202409.0307.v1
Abstract
This comprehensive analysis aims to offer valuable insights into the safety profiles of these glucocorticoids, facilitating the identification of compounds with potentially reduced adverse effects. This study investigates the toxicity profiles of various glucocorticoids, utilizing predictions from the pKCSM Server. Among the glucocorticoids examined, Dexamethasone, Triamcinolone, Hydrocortisone hemisuccinate, Paramethasone, Fluprednisolone, and Flumethasone emerge as potentially less toxic, displaying favorable scores across diverse parameters such as Max. Tolerated Dose (human, MRT), Oral Rat Acute Toxicity (LD50), and Oral Rat Chronic Toxicity (LOAEL). Notably, Hydrocortisone hemisuccinate and Triamcinolone stand out for their high tolerability capacity based on the Max. Tolerated Dose (human, MRT), suggesting enhanced safety profiles. These findings contribute insights into selecting glucocorticoids with optimal safety and tolerability for potential therapeutic applications.Further research and clinical investigations are warranted to validate and refine these findings, ensuring the responsible and effective use of glucocorticoids in medical practice.
Keywords
Max. Tolerated Dose; Triamcinolone; Oral Rat Acute Toxicity (LD50); pKCSM Server
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
