Preprint Review Version 1 This version is not peer-reviewed

Generative AI in Medicine and Healthcare: Moving Beyond the ‘Peak of Inflated Expectations’

Version 1 : Received: 2 September 2024 / Approved: 3 September 2024 / Online: 4 September 2024 (11:04:57 CEST)

How to cite: Zhang, P.; Shi, J.; Kamel Boulos, M. N. Generative AI in Medicine and Healthcare: Moving Beyond the ‘Peak of Inflated Expectations’. Preprints 2024, 2024090311. https://doi.org/10.20944/preprints202409.0311.v1 Zhang, P.; Shi, J.; Kamel Boulos, M. N. Generative AI in Medicine and Healthcare: Moving Beyond the ‘Peak of Inflated Expectations’. Preprints 2024, 2024090311. https://doi.org/10.20944/preprints202409.0311.v1

Abstract

The rapid development of specific-purpose Large Language Models (LLMs), such as Med-PaLM, MEDITRON-70B, and Med-Gemini, has significantly impacted healthcare, offering unprecedented capabilities in clinical decision support, diagnostics, and personalized health monitoring. This paper reviews the advancements in medicine-specific LLMs, the integration of Retrieval-Augmented Generation (RAG) and prompt engineering, and their applications in improving diagnostic accuracy and educational utility. Despite the potential, these technologies present challenges, including bias, hallucinations, and the need for robust safety protocols. The paper also discusses the regulatory and ethical considerations necessary for integrating these models into mainstream healthcare. By examining current studies and developments, this paper aims to provide a comprehensive overview of the state of LLMs in medicine and highlight the future directions for research and application. The study concludes that while LLMs hold immense potential, their safe and effective integration into clinical practice requires rigorous testing, ongoing evaluation, and continuous collaboration among stakeholders.

Keywords

generative AI; large language models; AI chatbots; ChatGPT; artificial intelligence; retrieval-augmented generation; medicine; healthcare; human health; AI regulation

Subject

Medicine and Pharmacology, Other

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