Version 1
: Received: 3 September 2024 / Approved: 3 September 2024 / Online: 4 September 2024 (08:33:45 CEST)
How to cite:
Golf, S.; Munoz-Ballester, C.; Heithoff, B.; George, K.; Robel, S. Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction. Preprints2024, 2024090315. https://doi.org/10.20944/preprints202409.0315.v1
Golf, S.; Munoz-Ballester, C.; Heithoff, B.; George, K.; Robel, S. Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction. Preprints 2024, 2024090315. https://doi.org/10.20944/preprints202409.0315.v1
Golf, S.; Munoz-Ballester, C.; Heithoff, B.; George, K.; Robel, S. Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction. Preprints2024, 2024090315. https://doi.org/10.20944/preprints202409.0315.v1
APA Style
Golf, S., Munoz-Ballester, C., Heithoff, B., George, K., & Robel, S. (2024). Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction. Preprints. https://doi.org/10.20944/preprints202409.0315.v1
Chicago/Turabian Style
Golf, S., Kijana George and Stefanie Robel. 2024 "Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction" Preprints. https://doi.org/10.20944/preprints202409.0315.v1
Abstract
Proper blood-brain barrier (BBB) function is essential to maintain homeostasis keeping the central nervous system healthy. Disruption of the BBB has been described in nearly all neurological disease and injury contexts. Given the various physical and metabolic roles of the BBB and gliovascular unit (GVU), dysfunction should be assessed across multiple levels to pinpoint the exact nature of the impairment. Here we describe imaging techniques for evaluating various aspects of BBB and GVU integrity and function, tailored for use in mouse models with protocols for quantitative image analysis. These imaging techniques complement classical dye tracer experiments and reveal underlying molecular causes of BBB dysfunction.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.