Version 1
: Received: 5 September 2024 / Approved: 6 September 2024 / Online: 9 September 2024 (02:54:54 CEST)
How to cite:
Yang, Z.; Zhang, Y.; Cao, Z.; Li, Z.; Zhang, L.; Yang, L. Early Pregnancy Influences the Expression of Estrogen Receptors in the Ovine Thymus, Lymph Node, Spleen, and Liver. Preprints2024, 2024090493. https://doi.org/10.20944/preprints202409.0493.v1
Yang, Z.; Zhang, Y.; Cao, Z.; Li, Z.; Zhang, L.; Yang, L. Early Pregnancy Influences the Expression of Estrogen Receptors in the Ovine Thymus, Lymph Node, Spleen, and Liver. Preprints 2024, 2024090493. https://doi.org/10.20944/preprints202409.0493.v1
Yang, Z.; Zhang, Y.; Cao, Z.; Li, Z.; Zhang, L.; Yang, L. Early Pregnancy Influences the Expression of Estrogen Receptors in the Ovine Thymus, Lymph Node, Spleen, and Liver. Preprints2024, 2024090493. https://doi.org/10.20944/preprints202409.0493.v1
APA Style
Yang, Z., Zhang, Y., Cao, Z., Li, Z., Zhang, L., & Yang, L. (2024). Early Pregnancy Influences the Expression of Estrogen Receptors in the Ovine Thymus, Lymph Node, Spleen, and Liver. Preprints. https://doi.org/10.20944/preprints202409.0493.v1
Chicago/Turabian Style
Yang, Z., Leying Zhang and Ling Yang. 2024 "Early Pregnancy Influences the Expression of Estrogen Receptors in the Ovine Thymus, Lymph Node, Spleen, and Liver" Preprints. https://doi.org/10.20944/preprints202409.0493.v1
Abstract
Estrogen exerts its action via estrogen receptors (ERs), including ERα and ERβ, and has effects on immunomodulation during pregnancy. It is known that there is a remodeling in maternal immunology during pregnancy. However, it is not clear if early pregnancy has effects on the expression of ERα and ERβ in the maternal thymus, lymph nodes, spleen, and liver. In this study, these maternal immune organs were harvested at day 16 of the estrous cycle, and at days 13, 16, and 25 of pregnancy. The mRNA and protein expression of ERα and ERβ was analyzed. The results revealed that mRNA and protein expression of both ERα and ERβ was upregulated in the maternal spleen, and expression of ERα and ERβ in the thymus, lymph nodes, and liver was modulated during early pregnancy. In conclusion, early pregnancy modulates the expression of ERα and ERβ in the maternal thymus, lymph nodes, spleen, and liver in a tissue-specific manner, which is related to the regulation of maternal immune function during early pregnancy.
Keywords
estrogen receptor; immune organ; pregnancy; sheep
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
