Version 1
: Received: 6 September 2024 / Approved: 6 September 2024 / Online: 9 September 2024 (07:58:58 CEST)
How to cite:
Adorisio, S.; Fierabracci, A.; Cham, B. T.; Vudinh, H. D.; Thuy Linh, N. T.; Nhung, L. T. H.; Ayroldi, E.; di giacomo, S.; Thuy, T. T.; Delfino, D. V. Cucurbitacin D from Elaeocarpus hainanensis Modulates ZNF217 in NPM-Mutated Acute Myeloid Leukemia. Preprints2024, 2024090570. https://doi.org/10.20944/preprints202409.0570.v1
Adorisio, S.; Fierabracci, A.; Cham, B. T.; Vudinh, H. D.; Thuy Linh, N. T.; Nhung, L. T. H.; Ayroldi, E.; di giacomo, S.; Thuy, T. T.; Delfino, D. V. Cucurbitacin D from Elaeocarpus hainanensis Modulates ZNF217 in NPM-Mutated Acute Myeloid Leukemia. Preprints 2024, 2024090570. https://doi.org/10.20944/preprints202409.0570.v1
Adorisio, S.; Fierabracci, A.; Cham, B. T.; Vudinh, H. D.; Thuy Linh, N. T.; Nhung, L. T. H.; Ayroldi, E.; di giacomo, S.; Thuy, T. T.; Delfino, D. V. Cucurbitacin D from Elaeocarpus hainanensis Modulates ZNF217 in NPM-Mutated Acute Myeloid Leukemia. Preprints2024, 2024090570. https://doi.org/10.20944/preprints202409.0570.v1
APA Style
Adorisio, S., Fierabracci, A., Cham, B. T., Vudinh, H. D., Thuy Linh, N. T., Nhung, L. T. H., Ayroldi, E., di giacomo, S., Thuy, T. T., & Delfino, D. V. (2024). Cucurbitacin D from <em>Elaeocarpus hainanensis</em> Modulates ZNF217 in NPM-Mutated Acute Myeloid Leukemia. Preprints. https://doi.org/10.20944/preprints202409.0570.v1
Chicago/Turabian Style
Adorisio, S., Trinh Thi Thuy and Domenico vittorio Delfino. 2024 "Cucurbitacin D from <em>Elaeocarpus hainanensis</em> Modulates ZNF217 in NPM-Mutated Acute Myeloid Leukemia" Preprints. https://doi.org/10.20944/preprints202409.0570.v1
Abstract
The expression of the oncogene zinc-finger protein 217 (ZNF217) has been reported to play a central role in cancer development, resistance, and recurrence. Therefore, targeting ZNF217 has been proposed as a possible strategy to fight cancer, making necessary to discover novel com-pounds. The present work aims to characterize the chemopreventive properties of cucurbitacin D , a compound with a broad range of anticancer effectsin relation to the ZNF217 expression. Different cucurbitacins were isolated from the Vietnamese plant Elaeocarpus hainanensis. The purified compounds were tested on nucleophosmin-mutated acute myeloid leukemia and other hematology cancer to study their effects on viability, apoptosis, cell cycle and on the expression of ZNF217. Cucurbitacin D reduced the number of acute myeloid leukemia cells by increasing apoptosis and blocking cell cycle progression. It also significantly decreased ZNF217 expression but only in the OCI-AML3 Nucleophosmin-mutated cell line, but not in other hematologic cancers. The reduction in ZNF217 expression contributed significantly to the blocking of cell cycle progression but not to apoptosis as established by the silencing of the same gene. The obtained results suggest Cucurbitacin D as a promising molecule to target the mutated Nu-cleophosmin or its pathway in acute myeloid leukemia cells, although further studies are needed for in depth investigatiion of its specificity.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
