Version 1
: Received: 6 September 2024 / Approved: 9 September 2024 / Online: 9 September 2024 (11:54:34 CEST)
How to cite:
Ciortea, D.-A.; Petrea (Cliveți), C. L.; Bujoreanu Bezman, L.; Vivisenco, I. C.; Berbece, S. I.; Gurău, G.; Matei, M. N.; Nechita, A. Diagnostic Utility of Copeptin in Pediatric Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis. Preprints2024, 2024090679. https://doi.org/10.20944/preprints202409.0679.v1
Ciortea, D.-A.; Petrea (Cliveți), C. L.; Bujoreanu Bezman, L.; Vivisenco, I. C.; Berbece, S. I.; Gurău, G.; Matei, M. N.; Nechita, A. Diagnostic Utility of Copeptin in Pediatric Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis. Preprints 2024, 2024090679. https://doi.org/10.20944/preprints202409.0679.v1
Ciortea, D.-A.; Petrea (Cliveți), C. L.; Bujoreanu Bezman, L.; Vivisenco, I. C.; Berbece, S. I.; Gurău, G.; Matei, M. N.; Nechita, A. Diagnostic Utility of Copeptin in Pediatric Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis. Preprints2024, 2024090679. https://doi.org/10.20944/preprints202409.0679.v1
APA Style
Ciortea, D. A., Petrea (Cliveți), C. L., Bujoreanu Bezman, L., Vivisenco, I. C., Berbece, S. I., Gurău, G., Matei, M. N., & Nechita, A. (2024). Diagnostic Utility of Copeptin in Pediatric Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202409.0679.v1
Chicago/Turabian Style
Ciortea, D., Madălina Nicoleta Matei and Aurel Nechita. 2024 "Diagnostic Utility of Copeptin in Pediatric Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202409.0679.v1
Abstract
Background: Pediatric patients with polyuria polydipsia syndrome (PPS) represent a diagnostic challenge for clinicians because of the technical difficulties in performing the gold standard water deprivation test (WDT). Copeptin, a stable biomarker representing the C-terminal portion of the polypeptide chain of antidiuretic hormone, proves to be a more reliable diagnostic tool. Objective: To assess the diagnostic accuracy of copeptin baseline dosing, arginine/saline copeptin stimulation tests, and WDT. Establishing the diagnostic utility of copeptin in pediatrics, for differentiating central and nephrogenic diabetes insipidus, and primary polydipsia. Methods: comparative and non-comparative primary studies, relating to children, were included and searched for in PubMed, Cochrane Library, WOS, ScienceDirect, Scopus, Google Scholar, up to August 2024. QUADAS-2 tool was used to assess risk of bias and applicability. Meta-analyses used fixed effect models due to low heterogeneity and the HSROC model. Results: 11 studies included, with an overall Low bias, no significant applicability concerns. The mean pooled sensitivity = 0.98 (95% CI: 0.936–1.025), pooled specificity=0.947 (95% CI: 0.920–0.973), and AUC=0.972 (95% CI: 0.952–0.992), indicating excellent diagnostic accuracy. Conclusion: Stimulation methods for copeptin dosing represent effective and less invasive diagnostic test for children with PPS, and future development of standard copeptin testing protocols are needed.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
