PreprintArticleVersion 1This version is not peer-reviewed
The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation
Version 1
: Received: 9 September 2024 / Approved: 9 September 2024 / Online: 10 September 2024 (07:28:47 CEST)
How to cite:
Foresto, R. D.; Souza, R. M.; dos Anjos, G. R.; Nakamura, M. R.; Goulart, H. D. S.; da Silva, R. S.; França, D. P.; Marques, E. F.; Lucena, E. F.; Cristelli, M. P.; Tedesco-Silva, H.; Requião-Moura, L.; Pestana, J. M. The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation. Preprints2024, 2024090728. https://doi.org/10.20944/preprints202409.0728.v1
Foresto, R. D.; Souza, R. M.; dos Anjos, G. R.; Nakamura, M. R.; Goulart, H. D. S.; da Silva, R. S.; França, D. P.; Marques, E. F.; Lucena, E. F.; Cristelli, M. P.; Tedesco-Silva, H.; Requião-Moura, L.; Pestana, J. M. The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation. Preprints 2024, 2024090728. https://doi.org/10.20944/preprints202409.0728.v1
Foresto, R. D.; Souza, R. M.; dos Anjos, G. R.; Nakamura, M. R.; Goulart, H. D. S.; da Silva, R. S.; França, D. P.; Marques, E. F.; Lucena, E. F.; Cristelli, M. P.; Tedesco-Silva, H.; Requião-Moura, L.; Pestana, J. M. The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation. Preprints2024, 2024090728. https://doi.org/10.20944/preprints202409.0728.v1
APA Style
Foresto, R. D., Souza, R. M., dos Anjos, G. R., Nakamura, M. R., Goulart, H. D. S., da Silva, R. S., França, D. P., Marques, E. F., Lucena, E. F., Cristelli, M. P., Tedesco-Silva, H., Requião-Moura, L., & Pestana, J. M. (2024). The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation. Preprints. https://doi.org/10.20944/preprints202409.0728.v1
Chicago/Turabian Style
Foresto, R. D., Lúcio Requião-Moura and Jose Medina Pestana. 2024 "The Influence of Initial Immunosuppression on the Kinetics of Humoral Response after SARS-CoV-2 Vaccination in Patients Undergoing Kidney Transplantation" Preprints. https://doi.org/10.20944/preprints202409.0728.v1
Abstract
The effect of initial immunosuppressive therapy on the kinetics of the SARS-CoV-2 vaccine-induced humoral response is unknown. Here, we compared the kinetics of SARS-CoV-2 vaccine-induced humoral response in chronic kidney disease patients undergoing kidney transplantation (KTRs) and compared to patients remaining on dialysis during the Omicron circulation. This prospective, non-randomized, real-world study included 113 KTRs and 108 patients on dialysis. Those with previous COVID-19 or negative IgG at screening were excluded. Blood samples were collected to assess SARS-CoV-2 IgG titers and neutralizing antibodies at months (M) 1, 3, 6, and 12. Seroreversion occurred in 1 KTR and in 3 patients on dialysis. KTRs had lower IgG titers over time (M1: 10,809.3±12,621.7 vs. 15,267.8±16,096.2 IU/mL; M3: 12,215.5±12,885.8 vs. 15,016.2±15,346.1 IU/mL; M6: 12,540.4±13,010.7 vs. 18,503.5±14,581.0 IU/mL; p=0.005), but Neutralizing antibodies were similar (M1: 94.0 vs. 90.3%; M3: 92.9 vs. 90.5%; M6: 99.0 vs. 95.5%; M12: 98.9 vs. 97.5%; p=0.812). During follow-up, KTRs received more vaccine (141 vs. 73; p<0,001) and had more COVID-19 (32.7% vs. 14.8%; p=0.002). Compared to patients on dialysis, KTRs had lower SARS-CoV-2 IgG titers and similar rates of seroreversion and neutralizing antibodies over time. Although KTRs received more boosters, they had a higher incidence of COVID-19.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
