PreprintArticleVersion 1This version is not peer-reviewed
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium brevis BBr60 Intervention: A Randomized Controlled Trial
Version 1
: Received: 10 September 2024 / Approved: 10 September 2024 / Online: 10 September 2024 (13:38:58 CEST)
How to cite:
Bai, Z.; Wu, Y.; Gao, D.; Dong, Y.; Pan, Y.; Gu, S. Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium brevis BBr60 Intervention: A Randomized Controlled Trial. Preprints2024, 2024090808. https://doi.org/10.20944/preprints202409.0808.v1
Bai, Z.; Wu, Y.; Gao, D.; Dong, Y.; Pan, Y.; Gu, S. Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium brevis BBr60 Intervention: A Randomized Controlled Trial. Preprints 2024, 2024090808. https://doi.org/10.20944/preprints202409.0808.v1
Bai, Z.; Wu, Y.; Gao, D.; Dong, Y.; Pan, Y.; Gu, S. Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium brevis BBr60 Intervention: A Randomized Controlled Trial. Preprints2024, 2024090808. https://doi.org/10.20944/preprints202409.0808.v1
APA Style
Bai, Z., Wu, Y., Gao, D., Dong, Y., Pan, Y., & Gu, S. (2024). Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss <em>Bifidobacterium brevis </em>BBr60 Intervention: A Randomized Controlled Trial. Preprints. https://doi.org/10.20944/preprints202409.0808.v1
Chicago/Turabian Style
Bai, Z., Yujia Pan and Shaobin Gu. 2024 "Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss <em>Bifidobacterium brevis </em>BBr60 Intervention: A Randomized Controlled Trial" Preprints. https://doi.org/10.20944/preprints202409.0808.v1
Abstract
Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 overweight or obese young adults, randomly assigned to either a Bifidobacterium brevis BBr60 group or a placebo group. Both groups received diet guidance and took either BBr60 (1×1010 CFU/day) or a placebo for 12 weeks. Re-searchers analyzed body composition, serum glucose, lipids, liver and kidney function, comprehensive metabolome, and intestinal homeostasis before and after the intervention. After 12 weeks, BBr60 significantly reduced weight and BMI compared to pre-treatment levels and outperformed the placebo. The BBr60 group also showed improved blood biochemistry, with notably lower fasting blood glucose (FBG) levels than the placebo group (p < 0.05). Additionally, BBr60 influenced vital serum and fecal metabolites related to three amino acid metabolic pathways and regulated the bacteria Dialister, Klebsiella, and Bacteroides, which correlated strongly with serum metabolites. These findings indicate that BBr60 can safely and effectively regulating BMI, body weight, serum glucose, lipids, and liver function markers, which may involve BBr60's impact on key gut bacteria, which influence metabolites related to the valine, leucine, and isoleucine biosynthesis; glycine, serine, and threonine metabolism; and alanine, aspartate, and glutamate metabolism.
Keywords
Bifidobacterium brevis BBr60; overweight or obese; randomized controlled trial; gut microbiota; metabolic profile
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
