Version 1
: Received: 10 September 2024 / Approved: 10 September 2024 / Online: 11 September 2024 (12:37:39 CEST)
How to cite:
Yordanova, R.; Strashimirov, D.; Grozdeva, R.; Ivanov, D.; Trifonova, I.; Yancheva, N.; Tcherveniakova, A. T. Dynamics of Biomarkers in COVID-19 Patients Treated with Anakinra. Preprints2024, 2024090840. https://doi.org/10.20944/preprints202409.0840.v1
Yordanova, R.; Strashimirov, D.; Grozdeva, R.; Ivanov, D.; Trifonova, I.; Yancheva, N.; Tcherveniakova, A. T. Dynamics of Biomarkers in COVID-19 Patients Treated with Anakinra. Preprints 2024, 2024090840. https://doi.org/10.20944/preprints202409.0840.v1
Yordanova, R.; Strashimirov, D.; Grozdeva, R.; Ivanov, D.; Trifonova, I.; Yancheva, N.; Tcherveniakova, A. T. Dynamics of Biomarkers in COVID-19 Patients Treated with Anakinra. Preprints2024, 2024090840. https://doi.org/10.20944/preprints202409.0840.v1
APA Style
Yordanova, R., Strashimirov, D., Grozdeva, R., Ivanov, D., Trifonova, I., Yancheva, N., & Tcherveniakova, A. T. (2024). Dynamics of Biomarkers in COVID-19 Patients Treated with Anakinra. Preprints. https://doi.org/10.20944/preprints202409.0840.v1
Chicago/Turabian Style
Yordanova, R., Nina Yancheva and and Tatiana Tcherveniakova. 2024 "Dynamics of Biomarkers in COVID-19 Patients Treated with Anakinra" Preprints. https://doi.org/10.20944/preprints202409.0840.v1
Abstract
A prospective clinical-epidemiological study was conducted to evaluate the dynamics of biomarkers in hospitalized patients with moderate to severe COVID-19 (according to the National Institute of Health severity scale) treated with Anakinra, compared to those receiving standard treatment. The study included 65 patients with a mean age of 75.51±9.54 years, ranging from 44 to 99 years. Among the study participants, 38 (58.5%) were male and 27 (41.5%) were female. The patients were divided into two groups: control group (standard treatment): 24 patients (36.9%) and target group (Anakinra treatment): 41 patients (63.1%). The results showed a significant relationship between the dynamics of leukocytes, ASAT, LDH, D-dimer, ferritin, and IL-6 and the administration of Anakinra. In the control group, no significant dynamics were observed in leukocyte count, D-dimer, ferritin, or IL-6. A statistically significant decrease in ASAT and LDH values in the control group was noted only on Day 7. In the Anakinra group, significantly (or with borderline statistical significance, p<0.1) lower mean values were observed for leukocytes, NLR, D-dimer, ferritin, and IL-6 on Days 3 and 7 compared to the control group. Additionally, significantly lower CRP values were detected in the Anakinra group on Day 7 compared to the control group.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
