Preprint Article Version 1 This version is not peer-reviewed

Gemcitabine Delivery System Based on Chitosan Capsules with Magnetite and Natural Zeolite (Clinoptilolite). Synthesis, Characterization and Evaluation of Its Anticancer and Bactericidal Properties

Yuly Andrea Guarín-González
* ,
Gerardo Cabello-Guzman
,
José Reyes-Gasga
,
Yanko Moreno-Navarro
,
Luis Vergara-González
,
Antonia Martin-Martín
,
Rodrigo López-Muñoz
,
Galo Cárdenas-Triviño
,
Luis Felipe Barraza
*
Version 1 : Received: 10 September 2024 / Approved: 10 September 2024 / Online: 11 September 2024 (10:22:01 CEST)

How to cite: Guarín-González, Y. A.; Cabello-Guzman, G.; Reyes-Gasga, J.; Moreno-Navarro, Y.; Vergara-González, L.; Martin-Martín, A.; López-Muñoz, R.; Cárdenas-Triviño, G.; Barraza, L. F. Gemcitabine Delivery System Based on Chitosan Capsules with Magnetite and Natural Zeolite (Clinoptilolite). Synthesis, Characterization and Evaluation of Its Anticancer and Bactericidal Properties. Preprints 2024, 2024090846. https://doi.org/10.20944/preprints202409.0846.v1 Guarín-González, Y. A.; Cabello-Guzman, G.; Reyes-Gasga, J.; Moreno-Navarro, Y.; Vergara-González, L.; Martin-Martín, A.; López-Muñoz, R.; Cárdenas-Triviño, G.; Barraza, L. F. Gemcitabine Delivery System Based on Chitosan Capsules with Magnetite and Natural Zeolite (Clinoptilolite). Synthesis, Characterization and Evaluation of Its Anticancer and Bactericidal Properties. Preprints 2024, 2024090846. https://doi.org/10.20944/preprints202409.0846.v1

Abstract

Cancer and infectious diseases are two of the world's major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules by incorporating GEM into a chitosan matrix blended with magnetite and zeolite. The physico-chemical characterization of the precursor materials and the new delivery system was carried out by HRTEM-ED, XRD, FESEM-EDS, FT-IR, TGA, encapsulation efficiency (%E.E.) and release profiles at pH 7.4 and 5.0. Cell viability tests on A549 and H1299 cell lines and microbiological properties against staphylococcal strains were performed. Our results revealed the successful production of hemispherical capsules with an average diameter of 1.22 mm, a rough surface and characteristic FT-IR material interaction bands. GEM encapsulation rates exceeded 80%, and release profiles were well-controlled over 24 hours at tested pH levels. Notably, cell viability in H1299 cells was lower than the free GEM control. Moreover, the formulation exhibited potent antimicrobial activity against Staphylococcus epidermidis, highlighting its dual action as a chemotherapeutic and antimicrobial agent. This dual effect underscores the potential of these macrocapsules as innovative delivery system for treating lung cancer in patients who are also at risk of infectious diseases and who are immunosuppressed.

Keywords

chitosan; magnetic nanoparticles; zeolite clinoptilolite; gemcitabine; drug carriers; ionic gelation

Subject

Chemistry and Materials Science, Applied Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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